Measuring Cognitive Judgement Bias in Rats Using the Ambiguous-Cue Interpretation Test

Q2 Neuroscience

Current Protocols in Neuroscience Pub Date : 2017-01-01 DOI:10.1002/cpns.19

Justyna Papciak, Rafal Rygula

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引用次数: 7

Abstract

An active-choice, operant, ambiguous-cue interpretation (ACI) paradigm is described that can be used for measuring cognitive judgement bias in rats. In this behavioral test, animals in an operant conditioning chamber are trained to press a lever to receive a food reward when a specific tone is presented, and to press another lever in response to a different tone to avoid punishment by an electric foot-shock. The tones, which serve as discriminative stimuli, acquire a positive or negative valence, and the training continues until the rats demonstrate a stable, correct discrimination between these two stimuli. The animals are tested after they have attained stable discrimination performance. The ambiguous-cue test consists of a discrimination task, as described above, but includes the presentation of additional tones with frequencies that are intermediate between the trained positive and negative tones. The lever-press response pattern to these ambiguous cues is considered an indicator of the rat's expectation of a positive or negative event; in other words, it is a measure of 'optimism' or 'pessimism', respectively. © 2017 by John Wiley & Sons, Inc.

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用模糊线索解释测试法测量大鼠的认知判断偏差

描述了一种主动选择、操作性、模糊线索解释（ACI）范式，可用于测量大鼠的认知判断偏差。在这项行为测试中，在操作性条件反射室内的动物被训练在出现特定音调时按下一个杠杆以获得食物奖励，并在不同音调时按下另一个杠杆，以避免受到脚触电的惩罚。作为辨别刺激的音调会获得正价或负价，训练会继续进行，直到大鼠在这两种刺激之间表现出稳定、正确的辨别能力。动物在获得稳定的辨别能力后进行测试。如上所述，模糊提示测试包括辨别任务，但包括呈现频率在训练的阳性音调和阴性音调之间的附加音调。对这些模糊线索的杠杆按压反应模式被认为是大鼠对积极或消极事件的预期的指标；换句话说，它分别是“乐观”或“悲观”的衡量标准。©2017 John Wiley&；股份有限公司。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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