Immunochemical studies on blood groups-LXVIII

Immunochemistry Pub Date : 1978-11-01 DOI:10.1016/0161-5890(78)90100-1

Hlvin A. Kabat , Jerry Liao , Raymond U. Lemieux

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引用次数: 41

Abstract

Oligosaccharide inhibition studies using anti-I Ma (group 1) showed thatdGalβl → 4dGlcNAcβl → 6dGal its βl → O-(CH₂)₈COOCH₃ glycoside and OGR_L1.1 (dGalβl → 4dGlcNAcβl → 6-3,4-dideoxy-hex-3-enitols) were equally active on a molar basis defining the anti-I Ma (group 1) site as complementary todGalβl → 4dGlcNAcβl → OCH₂-. The 1 → 3,1 → 6 compound showed very weak activity, the 1 → 4.1 → 3 and 1 → 3.1 → 3 compounds and the βl → O-(CH₂)₈COOCH₃ glycosides of these three latter compounds were inactive in the range studied. The anti-S XIV site differs from the anti-I Ma site in thatdGalβl → 4dGlcNAcβl → 6dGal was only slightly better thandGalβl → 4dGlcNAcβl → 3dGal and both were only about 1–3 more active thandGalβl → 4dGlcNAc. All compounds were inactive in the amounts available (1–2 μM) with anti-I Step and Nay (group 3), Phi and AJ (group 6) and anti-i Den.

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血型- lxviii的免疫化学研究

使用抗I Ma的低聚糖抑制研究（第1组）表明，dGalβ1→ 4dGlcNAcβl→ 6dGal及其βl→ O-（CH2）8COOCH3糖苷和OGRL1.1（dGalβl→ 4dGlcNAcβl→ 6-3,4-二脱氧-hex-3-烯醇）在摩尔基础上具有相同的活性，将抗I-Ma（第1组）位点定义为互补todGalβl→ 4dGlcNAcβl→ OCH2-。1→ 3,1→ 6化合物表现出非常弱的活性→ 4.1→ 3和1→ 3.1→ 3个化合物和βl→ 后三种化合物的O-（CH2）8COOCH3糖苷在所研究的范围内是无活性的。抗-SXIV位点与抗I-Ma位点的不同之处在于dGalβ1→ 4dGlcNAcβl→ 6dGal仅略好于dGalβl→ 4dGlcNAcβl→ 3dGal和两者的活性仅比dGalβl高约1-3→ 4dGlcNAc。所有化合物的可用量（1-2μM）均为无活性，抗I Step和Nay（第3组）、Phi和AJ（第6组）以及抗I Den。

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Immunochemistry

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