{"title":"Framingham equations overestimate risk of coronary heart disease mortality in British males","authors":"Mandeep Singh MD, FACC (Commentary Author)","doi":"10.1016/j.ehbc.2004.03.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Question</h3><p>What is the predictive accuracy of the Framingham risk score for coronary heart disease in a UK population?</p></div><div><h3>Study Design</h3><p>Prospective cohort study.</p></div><div><h3>Main results</h3><p>The Framingham equation significantly over-predicted 10-year coronary heart disease (CHD) mortality (predicted mortality 4.1% vs<em>.</em> observed mortality 2.8%; over-prediction of risk 47%; <em>P</em><0.0001 for goodness of fit). The Framingham equation significantly over-predicted 10 year CHD event rate (predicted event rate 16.0% vs. observed event rate 10.2%; over-prediction of risk 57%; <em>P</em><0.0001 for goodness of fit).</p></div><div><h3>Authors’ conclusions</h3><p>The Framingham equations over-predict risk of CHD mortality and all fatal and non-fatal CHD events in a representative sample of British men. The disparity seen is likely to represent actual differences in the levels of CHD risk in the Framingham population and the British male population.</p></div>","PeriodicalId":100512,"journal":{"name":"Evidence-based Healthcare","volume":"8 3","pages":"Pages 131-132"},"PeriodicalIF":0.0000,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehbc.2004.03.001","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Evidence-based Healthcare","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1462941004000361","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Question
What is the predictive accuracy of the Framingham risk score for coronary heart disease in a UK population?
Study Design
Prospective cohort study.
Main results
The Framingham equation significantly over-predicted 10-year coronary heart disease (CHD) mortality (predicted mortality 4.1% vs. observed mortality 2.8%; over-prediction of risk 47%; P<0.0001 for goodness of fit). The Framingham equation significantly over-predicted 10 year CHD event rate (predicted event rate 16.0% vs. observed event rate 10.2%; over-prediction of risk 57%; P<0.0001 for goodness of fit).
Authors’ conclusions
The Framingham equations over-predict risk of CHD mortality and all fatal and non-fatal CHD events in a representative sample of British men. The disparity seen is likely to represent actual differences in the levels of CHD risk in the Framingham population and the British male population.