Estatinas en pacientes sin enfermedad cardiovascular: una revisión crítica

Abstract

It shows a critical review of meta-analysis assessing the efficacy of statins in primary prevention of cardiovascular disease. We searched MEDLINE, EMBASE and Cochrane (period: January 2000 to December 2011) for meta-analysis of randomized trials conducted to study the effect of statins in primary prevention of cardiovascular disease. We used PRISMA statement to evaluate accuracy and reliability of meta-analysis. We selected 9 meta-analysis (mean of patients: 88.006). Five studies found a benefit in mayor cardiovascular events (range of relative risk [RR]: 0.69–0.85). Seven meta-analysis obtained improvement in mayor coronary events (range of RR: 0.61–0.77). There was no agreement between the results of total mortality, coronary mortality and cerebrovascular events. This critical review of meta-analysis suggests a modest benefit of statins in a primary prevention set-up.