Management of metastatic bone disease of melanoma.

IF 1.5 4区医学 Q3 DERMATOLOGY

Melanoma Research Pub Date : 2024-02-01 Epub Date: 2023-11-07 DOI:10.1097/CMR.0000000000000937

Wenyan Chen, Chen Yang, Biqi Chen, Mian Xi, Baoqing Chen, Qiaoqiao Li

引用次数: 0

Abstract

One of the most aggressive tumors arising from the skin, mucosa, and uvea is malignant melanoma, which easily metastasizes. Bone tissue is one of the most typical locations for distant metastasis, and around 5%-20% of patients eventually acquired skeletal metastases. For decades, the incidence of bone metastases was higher, bringing greater burden on the family, society, and healthcare system owing to the progress of targeted therapy and immunotherapy, which prolonging the survival time substantially. Moreover, bone metastases result in skeletal-related events, which influence the quality of life, obviously. Appropriate intervention is therefore crucial. To obtain the optimum cost-effectiveness, existing treatment algorithm must be integrated, which is still controversial. We have aimed to throw light on current views concerning the formation, biological and clinical features, and treatment protocol of melanoma bone metastases to guide the decision-making process.

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黑色素瘤转移性骨病的治疗。

由皮肤、粘膜和葡萄膜引起的最具侵袭性的肿瘤之一是恶性黑色素瘤，它很容易转移。骨组织是远处转移最典型的部位之一，约5%-20%的患者最终获得骨转移。几十年来，由于靶向治疗和免疫疗法的进步，骨转移的发生率更高，给家庭、社会和医疗系统带来了更大的负担，大大延长了生存时间。此外，骨转移会导致骨骼相关事件，从而明显影响生活质量。因此，适当的干预至关重要。为了获得最佳的成本效益，必须集成现有的治疗算法，这仍然是有争议的。我们旨在阐明目前关于黑色素瘤骨转移的形成、生物学和临床特征以及治疗方案的观点，以指导决策过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Research 医学-皮肤病学

CiteScore

3.40

自引率

4.50%

发文量

139

审稿时长

6-12 weeks

期刊介绍： Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.