Immunological Approaches in the Treatment of Diabetic Nephropathy.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Fatemeh Pour-Reza-Gholi, Sara Assadiasl
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引用次数: 0

Abstract

Diabetic nephropathy (DN), the leading cause of end-stage renal disease, has no definite treatment so far. In fact, a combination of metabolic, hemodynamic, and immunological factors are involved in the pathogenesis of DN; therefore, effective disease management requires a holistic approach to all predisposing contributors. Due to the recent findings about the role of inflammation in the initiation and progression of kidney injury in diabetic patients and considerable advances in immunotherapy methods, it might be useful to revise and reconsider the current knowledge of the potential of immunomodulation in preventing and attenuating DN. In this review, we have summarized the findings of add-on therapeutic methods that have concentrated on regulating inflammatory responses in diabetic nephropathy, including phosphodiesterase inhibitors, nuclear factor-kB inhibitors, Janus kinase inhibitors, chemokine inhibitors, anti-cytokine antibodies, cell therapy, and vaccination.

糖尿病肾病的免疫学治疗方法。
糖尿病肾病(DN)是导致终末期肾病的主要原因,目前尚无明确的治疗方法。事实上,代谢、血液动力学和免疫因素的结合参与了DN的发病机制;因此,有效的疾病管理需要对所有易感因素采取全面的方法。由于最近发现炎症在糖尿病患者肾损伤的发生和发展中的作用,以及免疫治疗方法的长足进步,修订和重新考虑免疫调节在预防和减轻DN中的潜力的现有知识可能是有用的。在这篇综述中,我们总结了专注于调节糖尿病肾病炎症反应的附加治疗方法的发现,包括磷酸二酯酶抑制剂、核因子κB抑制剂、Janus激酶抑制剂、趋化因子抑制剂、抗细胞因子抗体、细胞治疗和疫苗接种。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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