{"title":"<i>IL-6</i> gene polymorphism predicts PEGylated IFN-α treatment response in hepatitis B surface antigen-positive chronic hepatitis B patients.","authors":"Xiaoqing Wang, Xiu Gu, Fengli Liu","doi":"10.2217/pme-2023-0089","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Genetic polymorphism can affect the response to antiviral therapy of chronic hepatitis B (CHB) patients. <b>Objective:</b> The study examined the genetic association of the <i>IL-6</i> rs1800796 polymorphism with PEGylated IFN-α (PegIFN-α) treatment response in hepatitis B surface antigen (HBsAg)-positive CHB patients. <b>Methods:</b> Direct sequencing was done for the genotyping of the rs1800796 polymorphism in the serum of CHB patients. <b>Results:</b> More patients with combined response (n = 95) carried <i>IL-6</i> rs1800796 GC genotypes, while CC genotype carriers possessed reduced HBeAg seroconversion rate and high values of hepatitis B virus DNA. Baseline HBsAg and HBeAg and <i>IL-6</i> rs1800796 CC genotype were independently related to PegIFN-α treatment response. <b>Conclusion:</b> Detection of the <i>IL-6</i> rs1800796 genotype in CHB patients may have potential guiding significance for PegIFN-α response.</p>","PeriodicalId":94167,"journal":{"name":"Personalized medicine","volume":" ","pages":"503-510"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/pme-2023-0089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Genetic polymorphism can affect the response to antiviral therapy of chronic hepatitis B (CHB) patients. Objective: The study examined the genetic association of the IL-6 rs1800796 polymorphism with PEGylated IFN-α (PegIFN-α) treatment response in hepatitis B surface antigen (HBsAg)-positive CHB patients. Methods: Direct sequencing was done for the genotyping of the rs1800796 polymorphism in the serum of CHB patients. Results: More patients with combined response (n = 95) carried IL-6 rs1800796 GC genotypes, while CC genotype carriers possessed reduced HBeAg seroconversion rate and high values of hepatitis B virus DNA. Baseline HBsAg and HBeAg and IL-6 rs1800796 CC genotype were independently related to PegIFN-α treatment response. Conclusion: Detection of the IL-6 rs1800796 genotype in CHB patients may have potential guiding significance for PegIFN-α response.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
