Sub-optimal maternal gestational gain is associated with shorter leukocyte telomere length at birth in a predominantly Latinx cohort of newborns.

Maternal health, neonatology and perinatology Pub Date : 2023-11-03 DOI:10.1186/s40748-023-00167-z

Apurva Prasad, Jue Lin, Laura Jelliffe-Pawlowski, Kimberley Coleman-Phox, Larry Rand, Janet M Wojcicki

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Abstract

Objective: To assess in utero exposures associated with leukocyte telomere length (LTL) at birth and maternal LTL in a primarily Latinx birth cohort.

Study design: Mothers and newborns were recruited postnatally before 24 h of life. Newborn LTL was collected via heelstick at birth and maternal LTL was collected postnatally. LTL was determined by quantitative PCR. Using a longitudinal design, we evaluated associations between neonatal and maternal LTL and appropriate maternal gestational gain as indicated by the American College of Obstetrics and Gynecology (ACOG).

Result: Mean infant LTL was 2.02 ± 0.30 T/S (n = 386) and maternal LTL was 1.54 ± 0.26 T/S (n = 58). Independent risk factors for shorter LTL at birth included longer gestational duration (Coeff:-0.03, 95%CI: -0.05-0.01;p < 0.01) and maternal gestational weight gain below ACOG recommendations (Coeff:-0.10, 95%CI: -0.18 - -0.02; p = 0.01).

Conclusion: Gestational weight gain below ACOG recommendations may adversely impact neonatal health in Latinx infants as indicated by shorter LTL at birth.

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在以拉丁裔为主的新生儿队列中，次优母体妊娠增加与出生时白细胞端粒长度较短有关。

目的：在一个主要为拉丁裔的出生队列中，评估子宫内暴露与出生时白细胞端粒长度（LTL）和母体LTL相关。研究设计：母亲和新生儿在出生后24小时前被招募。新生儿LTL在出生时通过heelstick采集，产妇LTL在产后采集。LTL通过定量PCR测定。根据美国妇产科学会（ACOG）的指示，我们使用纵向设计评估了新生儿和产妇LTL与适当的母体妊娠增加之间的关系。结果：婴儿平均LTL为2.02 ± 0.30 T/S（n = 386），母体LTL为1.54 ± 0.26 T/S（n = 58）。出生时LTL较短的独立危险因素包括妊娠期较长（Coeff:-0.03，95%CI:-0.05-0.01；p 结论：低于ACOG建议的妊娠期体重增加可能会对拉丁裔婴儿的新生儿健康产生不利影响，如出生时LTL较短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Maternal health, neonatology and perinatology

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12 weeks