HDL-C and creatinine levels at 1 month are associated with patient 12-month survival rate after kidney transplantation.

IF 1.7 3区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Pharmacogenetics and genomics Pub Date : 2024-02-01 Epub Date: 2023-12-04 DOI:10.1097/FPC.0000000000000514

Haolin Teng, Xinyuan Hu, Nian Liu

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引用次数: 0

Abstract

Background: Many factors affect the survival rate after kidney transplantation, including laboratory tests, medicine therapy and pharmacogenomics. Tacrolimus, mycophenolate mofetil and methylprednisolone were used as an immunosuppressive regimen after kidney transplantation. The primary goal of this study was to investigate the factors affecting the tacrolimus concentrations and mycophenolate mofetil area under the curve of mycophenolic acid AUC-MPA. Secondary goals were to study the association between perioperative period laboratory tests, medicine therapy, CYP3A5 genetic polymorphisms, and survival rate in kidney renal transplant patients.

Methods: A total of 303 patients aged above 18 years were enrolled in this study. Their clinical characteristics, laboratory tests, and medicine therapy regimens were collected. We followed the patients for survival for 1 year after kidney transplantation.

Results: Multivariable logistic analyses reveal that age greater than 50 years, and the CY3A5 *3*3 genotype were independently, positively, and significantly related to tacrolimus C/D ratio at 7 days. At 1 month of follow-up, only CYP3A5 *3*3 was associated with tacrolimus C/D ratio. Basiliximab, Imipenem and cilastatin sodium, sex were associated with mycophenolate mofetil AUC-MPA at 7 days. In the COX regression analysis, a high-density lipoprotein cholesterol level≥1 mmol/L was identified as a positive independent risk factors for the survival rate, while a creatinine level ≥200 μmol/L was a negatively independent risk factors for survival rate.

Conclusion: These results suggest that age, genes, and drug-drug interaction can affect the concentration of tacrolimus.

查看原文本刊更多论文

肾移植术后1个月HDL-C和肌酐水平与患者12个月生存率相关。

背景：影响肾移植术后存活率的因素很多，包括实验室检查、药物治疗和药物基因组学。肾移植后使用他克莫司、霉酚酸酯和甲基强的松龙作为免疫抑制方案。本研究的主要目的是在麦考酚酸AUC-MPA曲线下研究影响他克莫司浓度和麦考酚酯面积的因素。次要目标是研究肾移植患者围手术期实验室检查、药物治疗、CYP3A5基因多态性与生存率之间的关系。方法：本研究共纳入303名18岁以上的患者。收集他们的临床特征、实验室检查和药物治疗方案。我们对肾移植后的患者进行了1年的随访。结果：多变量logistic分析显示，年龄大于50岁和CY3A5*3*3基因型与他克莫司7天的C/D比率独立、呈正相关且显著。随访1个月时，只有CYP3A5*3*3与他克莫司C/D比率相关。在第7天，巴西利昔单抗、亚胺培南和西司他丁钠、性别与霉酚酸酯AUC-MPA相关。在COX回归分析中，高密度脂蛋白胆固醇水平≥1 mmol/L被确定为生存率的阳性独立危险因素，而肌酐水平≥200μmol/L是生存率的阴性独立危险因素。结论：年龄、基因和药物相互作用可能影响他克莫司的浓度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenetics and genomics 医学-生物工程与应用微生物

CiteScore

3.20

自引率

3.80%

发文量

审稿时长

3 months

期刊介绍： Pharmacogenetics and Genomics is devoted to the rapid publication of research papers, brief review articles and short communications on genetic determinants in response to drugs and other chemicals in humans and animals. The Journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics, clinical pharmacology, clinical pharmacy, epidemiology, genetics, genomics, molecular biology, pharmacology, pharmaceutical sciences, and toxicology. Under a single cover, the Journal provides a forum for all aspects of the genetics and genomics of host response to exogenous chemicals: from the gene to the clinic.