Blood-brain barrier permeability in the ischemic stroke: An update

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2023-10-31 DOI:10.1016/j.mvr.2023.104621

Khiany Mathias , Richard Simon Machado , Solange Stork , David dos Santos , Larissa Joaquim , Jaqueline Generoso , Lucinéia Gainski Danielski , Tatiana Barichello , Josiane Somariva Prophiro , Fabricia Petronilho

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引用次数: 0

Abstract

Stroke is the second leading cause of death globally and the major cause of long-term disability. Among the types of strokes, ischemic stroke, which occurs due to obstruction of blood vessels responsible for cerebral irrigation, is considered the most prevalent, accounting for approximately 86 % of all stroke cases. This interruption of blood supply leads to a critical pathophysiological mechanism, including oxidative stress and neuroinflammation which are responsible for structural alterations of the blood-brain barrier (BBB). The increased BBB permeability associated with cerebral ischemia-reperfusion may contribute to a worse outcome after stroke. Thus, this narrative review aims to update the pathophysiological mechanisms involved in the increase in BBB permeability and to list the possible therapeutic strategies.

查看原文本刊更多论文

缺血性脑卒中患者血脑屏障通透性的研究进展。

中风是全球第二大死亡原因，也是导致长期残疾的主要原因。在中风类型中，缺血性中风被认为是最常见的，约占86例，缺血性中风是由于负责脑灌注的血管阻塞而发生的 % 在所有中风病例中。这种血液供应的中断导致了一种关键的病理生理机制，包括氧化应激和神经炎症，这是血脑屏障（BBB）结构改变的原因。与脑缺血再灌注相关的血脑屏障通透性增加可能导致中风后更糟糕的结果。因此，这篇叙述性综述旨在更新血脑屏障通透性增加的病理生理机制，并列出可能的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.