Low serum creatinine as a prognostic marker in advanced cancer.

IF 2 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES

BMJ Supportive & Palliative Care Pub Date : 2025-04-30 DOI:10.1136/spcare-2023-004646

Koji Amano, Vickie Baracos, Satomi Okamura, Tomomi Yamada, Isseki Maeda, Hiroyuki Otani, Hiroto Ishiki, Tomofumi Miura, Jun Hamano, Yutaka Hatano, Tatsuya Morita, Masanori Mori

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引用次数: 0

Abstract

Objectives: To evaluate whether low serum creatinine levels are associated with poor outcomes in patients with advanced cancer.

Methods: This is a secondary analysis of a prospective cohort study. Patients were divided into three groups according to their baseline serum creatinine levels. We performed time-to-event analyses using the Kaplan-Meier method and log-rank tests, and by conducting univariate and multivariate Cox regression analyses.

Results: 809 males were divided: male-low group (n=192), male-normal group (n=403) and male-high group (n=214). 808 females were divided: female-low group (n=239), female-normal group (n=389) and female-high group (n=180). Significant differences were observed in survival rates between the high and normal groups in the males and females (both log-rank p<0.001). Significantly higher risks of mortality were observed in the Cox proportional hazard model for the high group than for the normal group in both sexes (adjusted HR 1.292, 95% CI 1.082 to 1.542; adjusted HR 1.316, 95% CI 1.094 to 1.583, respectively). High serum creatinine was associated with shorter survival than normal creatinine, while low serum creatinine was not.

Conclusions: Low serum creatinine levels did not have prognostic abilities in this population.

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低血清肌酸酐作为晚期癌症的预后标志物。

目的：评估血清肌酸酐水平低是否与晚期癌症患者的不良预后相关。方法：这是一项前瞻性队列研究的二次分析。根据患者的基线血清肌酸酐水平，将患者分为三组。我们使用Kaplan-Meier方法和对数秩检验进行了事件时间分析，并进行了单变量和多变量Cox回归分析。结果：809名男性分为男性低组（n=192）、男性正常组（n=403）和男性高组（n=214）。808名女性被分为女性低组（n=239）、女性正常组（n=389）和女性高组（n=180）。在男性和女性中，高组和正常组的生存率存在显著差异（均为对数秩P结论：在该人群中，低血清肌酐水平没有预后能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Supportive & Palliative Care Medicine-Medicine (miscellaneous)

CiteScore

4.60

自引率

7.40%

发文量

170

期刊介绍： Published quarterly in print and continuously online, BMJ Supportive & Palliative Care aims to connect many disciplines and specialties throughout the world by providing high quality, clinically relevant research, reviews, comment, information and news of international importance. We hold an inclusive view of supportive and palliative care research and we are able to call on expertise to critique the whole range of methodologies within the subject, including those working in transitional research, clinical trials, epidemiology, behavioural sciences, ethics and health service research. Articles with relevance to clinical practice and clinical service development will be considered for publication. In an international context, many different categories of clinician and healthcare workers do clinical work associated with palliative medicine, specialist or generalist palliative care, supportive care, psychosocial-oncology and end of life care. We wish to engage many specialties, not only those traditionally associated with supportive and palliative care. We hope to extend the readership to doctors, nurses, other healthcare workers and researchers in medical and surgical specialties, including but not limited to cardiology, gastroenterology, geriatrics, neurology, oncology, paediatrics, primary care, psychiatry, psychology, renal medicine, respiratory medicine.