A cryogen-free, semi-automated apparatus for bullet-dynamic nuclear polarization with improved resolution.

Q3 Physics and Astronomy
Magnetic resonance (Gottingen, Germany) Pub Date : 2021-11-11 eCollection Date: 2021-01-01 DOI:10.5194/mr-2-815-2021
Karel Kouřil, Michel Gramberg, Michael Jurkutat, Hana Kouřilová, Benno Meier
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引用次数: 0

Abstract

In dissolution-dynamic nuclear polarization, a hyperpolarized solid is dissolved with a jet of hot solvent. The solution is then transferred to a secondary magnet, where spectra can be recorded with improved sensitivity. In bullet-dynamic nuclear polarization this order is reversed. Pressurized gas is used to rapidly transfer the hyperpolarized solid to the secondary magnet, and the hyperpolarized solid is dissolved only upon arrival. A potential advantage of this approach is that it may avoid excessive dilution and the associated signal loss, in particular for small sample quantities. Previously, we have shown that liquid-state NMR spectra with polarization levels of up to 30 % may be recorded within less than 1 s after the departure of the hyperpolarized solid from the polarizing magnet. The resolution of the recorded spectra however was limited. The system consumed significant amounts of liquid helium, and substantial manual work was required in between experiments to prepare for the next shot. Here, we present a new bullet-DNP (dynamic nuclear polarization) system that addresses these limitations.

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一种用于弹头动态核极化的无冷冻剂半自动装置,具有改进的分辨率。
在溶解动力学核极化中,超极化固体用热溶剂射流溶解。然后将溶液转移到二次磁铁上,在那里可以以提高的灵敏度记录光谱。在弹头动态核极化中,这个顺序是相反的。加压气体用于将超极化固体快速转移到次级磁体,并且超极化固体仅在到达时溶解。这种方法的一个潜在优点是,它可以避免过度稀释和相关的信号损失,特别是对于小样本量。以前,我们已经证明了极化水平高达30的液态NMR光谱 % 可能在1以内记录 s。然而,记录的光谱的分辨率是有限的。该系统消耗了大量的液氦,在实验之间需要大量的手动工作来为下一次发射做准备。在这里,我们提出了一种新的子弹DNP(动态核极化)系统,以解决这些限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
0.00%
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审稿时长
14 weeks
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