TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension.

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2023-12-31 Epub Date: 2023-10-30 DOI:10.1080/10641963.2023.2272581

Jie Pang, Linyan Qian, Xiaoru Che, Ping Lv, Qiang Xu

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引用次数: 0

Abstract

Background: The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship between the TyG index and all-cause and cardiovascular mortality among middle-aged and elderly with hypertension.

Methods: A total of 3,614 participants with hypertension were enrolled from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The Cox proportional hazard ratios were used to evaluate the association between the TyG index and the risk of mortality.

Results: Over a follow-up period of 7.87 years, 991 all-cause death and 189 cardiovascular deaths occurred. Compared with the reference quartile, the multivariate-adjusted hazard ratios and 95% confidence intervals were 1.28 (1.07-1.53; p = .006) in the fourth quartile for all-cause mortality and 0.63 (0.42-0.96; p = .031) in the second quartile for cardiovascular mortality. Dose-response analysis indicated an L-shaped relationship.

Conclusions: The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.

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TyG指数是中老年高血压患者长期随访期间全因死亡率的预测指标。

背景：甘油三酯和葡萄糖（TyG）指数已被发现与较高的死亡率显著相关。然而，在中老年高血压患者中，缺乏探索TyG指数与全因死亡率和心血管死亡率之间具体关系的研究。方法：共有3614名高血压患者参加了国家健康和营养检查调查。TyG指数使用公式log[空腹甘油三酯（mg/dL）x空腹血糖（mg/dL）/2]计算。Cox比例风险比用于评估TyG指数与死亡率之间的相关性。结果：在7.87的随访期内多年来，发生了991例全因死亡和189例心血管死亡。与参考四分位数相比，多变量调整后的风险比和95%置信区间为1.28（1.07-1.53；p = .006）和0.63（0.42-0.96；p = .031）在心血管死亡率的第二四分位数中。剂量反应分析表明呈L型关系。结论：TyG指数与中老年高血压患者全因死亡率呈L型相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.