Atopic Dermatitis: Fertility, Pregnancy, and Treatment Perspectives

IF 8.6 1区 医学 Q1 DERMATOLOGY
Mónica Munera-Campos, Jose Manuel Carrascosa
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引用次数: 0

Abstract

Hormonal and immunologic changes during pregnancy can contribute to the development of different dermatoses, the most common of which is atopic eruption of pregnancy (AEP). Of atopic dermatitis (AD) cases during pregnancy, 80% are new-onset presentations, while 20% represent recurrences or exacerbations of preexisting disease. Evidence on the effects of previous AD on fertility is limited. Different factors influence women’s desire to conceive in this setting, and it has been hypothesized that barrier defects and systemic inflammation could contribute to biologic infertility, although more data are needed. Clinical practice suggests a tendency toward undertreatment in pregnant woman due to concerns about potential effects on obstetric and fetal outcomes. However, pregnant women should be offered adequate and safe treatments, preferably on an individual basis. The aim of this review was to summarize the evidence on disease course in pregnant women with AD and the challenges associated with its diagnosis and management. We also review the current evidence on the use of conventional and novel systemic therapies for AD in this population.

Abstract Image

特应性皮炎:生育、妊娠和治疗前景。
妊娠期间的激素和免疫变化会导致不同皮肤病的发展,其中最常见的是妊娠特应性皮疹(AEP)。在妊娠期间的特应性皮炎(AD)病例中,80%是新发性表现,而20%代表原有疾病的复发或恶化。关于既往AD对生育能力影响的证据有限。在这种情况下,不同的因素会影响女性的怀孕欲望,尽管还需要更多的数据,但有人假设屏障缺陷和全身炎症可能会导致生物性不孕。临床实践表明,由于担心对产科和胎儿结局的潜在影响,孕妇有治疗不足的趋势。然而,孕妇应该得到充分和安全的治疗,最好是个人治疗。这篇综述的目的是总结妊娠期AD患者病程的证据以及与诊断和管理相关的挑战。我们还回顾了在该人群中使用传统和新型系统疗法治疗AD的最新证据。
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来源期刊
CiteScore
15.20
自引率
2.70%
发文量
84
审稿时长
>12 weeks
期刊介绍: The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.
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