Suppressing spiral waves and spatiotemporal chaos in cardiac tissue by using calcium channel agonist

Abstract

Suppression of spiral waves and spatiotemporal chaos in cardiac tissue has been considered based on the LuoRudy 91 model. To suppress spiral waves and spatiotemporal chaos, the control strategy which employs calcium channel agonist to enhance the maximum conductivity of the slow inward calcium current is proposed. The numerical results show that the method can effectively suppress the spiral wave and spatiotemporal chaos in cardiac tissue even if the distribution of the time-dependent potassium current is non-uniform. The control mechanism has been analyzed.