Stem cells and heart: an open future or a mirage?

IF 0.3 Q4 PEDIATRICS

Journal of Pediatric and Neonatal Individualized Medicine Pub Date : 2016-01-27 DOI:10.7363/050102

P. Bassareo, G. Mercuro

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引用次数: 3

Abstract

Stem cells (SC) look like to be the possible solution to a number of human pathologies, including those involving the heart. In fact, some studies based on animal models suggest that SC can be used to repair the damaged cardiac tissue, such as in case of myocardial infarction. In fact it has been demonstrated that it would be possible to produce a quantity of SC sufficient to repair an animal heart having physiology and dimensions as the human heart. The aim of this short review is to examine the different subtypes of SC potentially involved in the heart repair (autologous and heterologous) processes as well as the serious concerns that have still to be overcome before considering SC a sure therapy for the heart diseases: rejections, oncogenesis due to SC high proliferative activity, difficult in ruling their differentiation, massive SC death when introducing them in an ischemic environment, ethical problems when SC are derived from embryos. Proceedings of the 2 nd International Course on Perinatal Pathology (part of the 11 th International Workshop on Neonatology · October 26 th -31 st , 2015) · Cagliari (Italy) · October 31 st , 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano

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干细胞和心脏:开放的未来还是海市蜃楼?

干细胞(SC)似乎是解决许多人类疾病的可能方法，包括那些涉及心脏的疾病。事实上，一些基于动物模型的研究表明，SC可以用于修复受损的心脏组织，例如心肌梗死。事实上，已经证明有可能产生足够数量的SC来修复具有人类心脏生理学和尺寸的动物心脏。这篇简短综述的目的是研究可能参与心脏修复(自体和异体)过程的SC的不同亚型，以及在考虑SC作为心脏病的可靠治疗方法之前仍需克服的严重问题:排斥反应，由于SC高增殖活性导致的肿瘤发生，难以控制其分化，在缺血环境中引入SC时大量死亡，胚源性SC时的伦理问题。第二届围产期病理学国际课程论文集(第11届新生儿国际研讨会的一部分·2015年10月26日至31日)·卡利亚里(意大利)·2015年10月31日·干细胞:现在和未来客座编辑:Gavino Faa, Vassilios Fanos, Antonio Giordano

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来源期刊

Journal of Pediatric and Neonatal Individualized Medicine PEDIATRICS-

CiteScore

1.00

自引率

25.00%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way. Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.