Melatonin for the newborn

IF 0.3 Q4 PEDIATRICS
L. Marseglia, S. Manti, G. D'angelo, E. Gitto, I. Barberi
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引用次数: 9

Abstract

Reactive oxygen species play an important role in the pathogenesis of several diseases during the perinatal and neonatal period. Melatonin, an effective direct free-radical scavenger and indirect antioxidant agent, diffuses through biological membranes easily and exerts pleiotropic actions on every cell. Several studies have tested the efficacy of melatonin to counteract oxidative damage in diseases of newborn such as chronic lung disease, perinatal brain injury, necrotizing enterocolitis and sepsis, giving promising results. The peculiar perinatal susceptibility to oxidative stress indicates that prophylactic use of antioxidants as melatonin could help to prevent or at least reduce oxidative stress related diseases in newborns. However, more studies are needed to confirm these beneficial effects. Proceedings of the 10 th International Workshop on Neonatology · Cagliari (Italy) · October 22 nd -25 th , 2014 ·  The last ten years, the next ten years in Neonatology Guest Editors: Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgiou
新生儿褪黑素
活性氧在围产期和新生儿期多种疾病的发病机制中起重要作用。褪黑素是一种有效的直接自由基清除剂和间接抗氧化剂,易于通过生物膜扩散,对每个细胞都有多效性作用。一些研究已经测试了褪黑素在新生儿疾病(如慢性肺病、围产期脑损伤、坏死性小肠结肠炎和败血症)中对抗氧化损伤的功效,并给出了令人鼓舞的结果。围产期对氧化应激的特殊易感性表明,预防性使用抗氧化剂如褪黑激素可以帮助预防或至少减少新生儿氧化应激相关疾病。然而,需要更多的研究来证实这些有益的影响。第十届国际新生儿科研讨会论文集·卡利亚里(意大利)·2014年10月22日至25日·过去的十年,未来的十年在新生儿科客座编辑:Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgiou
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来源期刊
CiteScore
1.00
自引率
25.00%
发文量
0
审稿时长
12 weeks
期刊介绍: The Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way. Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.
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