Seroprevalence of Rubella Virus Infection in Susceptible Women of Childbearing Age Group Seeking Preconceptional Counselling and Infertility Treatment- A Cross-sectional Study from Eastern India
Nidhi Prasad, Dipali Prasad, Vidyut Prakash, Kalpana Singh, K. Shashi, Sangeeta Pankaj, K. Bimal
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引用次数: 0
Abstract
Introduction: Rubella is an acute viral infection predominantly affecting children and adults. Although natural infection with rubella provide lifelong immunity, but, primary infection in pregnant women during the initial days of pregnancy may result in spontaneous abortion, stillbirth, or a baby born with Congenital Rubella Syndrome (CRS), which can be prevented by vaccinating the susceptible non immune females one month prior to planning conception. Aim: To determine rubella virus immune status and demographic profile of women in childbearing age group, and counsel all Rubella virus infection susceptible women for vaccination prior to planning pregnancy. Materials and Methods: A cross-sectional observational study was done at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna , Bihar, India, on 112 apparently healthy, asymptomatic women in the 18-45 years age group coming for preconceptional counselling and primary and secondary infertility treatment during April 2017 to March 2019, whose serum rubella Immunoglobulin G (IgG) antibody testing was done by Enzyme- linked Immunosorbent Assay (ELISA). The data regarding their rubella virus immune status, age, parity and occupations were coded and recorded in MS Excel spreadsheet program. The Statistical Package for the Social Sciences (SPSS) version 23 (IBM Corp.) was used for data analysis. Results: Out of the total 112 women {92 (82.1%) housewife and 20 (17.9%) professionals} included in this study , a total of 67 (59.8%) women tested positive for rubella IgG antibody and 45 (40.2%) tested negative for rubella IgG antibody. The mean age of the rubella virus seropositive immune patients and seronegative susceptible women was 27.72±4.83 years was 26.09±4.68 years respectively. Among the 67 seropositive patients, maximum antirubella virus IgG seropositivity (71.4%) was seen in more than 35 years age group and maximum seronegativity 23 (46.9%) was seen in 18-26 years age group. There was no direct association of occupation and parity with rubella immune status. Conclusion: Higher rate of antirubella IgG seronegativity amongst younger age groups and nulliparous women renders them susceptible to primary Rubella virus infection. Hence, Rubella IgG antibody screening, proper counselling and prompt rubella vaccination for all primary Rubella virus infection susceptible women is necessary one month prior to planning conception, to avoid foetal congenital malformations during subsequent pregnancies.
简介:风疹是一种急性病毒感染,主要影响儿童和成人。虽然自然感染风疹可提供终身免疫,但是,孕妇在怀孕最初几天的原发性感染可能导致自然流产、死产或出生时患有先天性风疹综合征(CRS)的婴儿,可通过在计划受孕前一个月为易感无免疫的女性接种疫苗来预防。目的:了解育龄妇女风疹病毒免疫状况和人口统计特征,建议所有风疹病毒感染易感妇女在计划怀孕前接种疫苗。材料和方法:在印度比哈尔邦帕特纳的英迪拉甘地医学科学研究所(IGIMS)对2017年4月至2019年3月期间来接受孕前咨询和原发性和继发性不孕症治疗的18-45岁年龄组的112名表面健康无症状妇女进行了横断面观察研究,其血清风疹免疫球蛋白G (IgG)抗体检测采用酶联免疫吸附试验(ELISA)。将患者的风疹病毒免疫状态、年龄、胎次、职业等数据编码并记录在MS Excel电子表格程序中。数据分析使用SPSS (Statistical Package for The Social Sciences) version 23 (IBM Corp.)。结果:本研究共纳入112名妇女(92名(82.1%)主妇和20名(17.9%)专业人员),其中67名(59.8%)妇女风疹IgG抗体阳性,45名(40.2%)妇女风疹IgG抗体阴性。风疹病毒血清阳性免疫患者和血清阴性易感妇女的平均年龄分别为27.72±4.83岁和26.09±4.68岁。67例血清阳性患者中,35岁以上年龄组抗风疹病毒IgG血清阳性最多(71.4%),18-26岁年龄组血清阴性最多(46.9%)。职业和胎次与风疹免疫状态无直接关联。结论:低龄人群和未生育妇女抗风疹IgG血清阴性率较高,易发生原发性风疹病毒感染。因此,有必要在计划受孕前一个月对所有原发性风疹病毒感染易感妇女进行风疹IgG抗体筛查、适当咨询和及时接种风疹疫苗,以避免在随后怀孕期间出现胎儿先天性畸形。