Study of Serum Magnesium, Potassium and their Correlation with Lipid Profile in Ischaemic Heart Disease

Arkajit Dasgupta, S. Maiti, J. Choudhury, Debojyoti Bhattacharjee
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Abstract

Introduction: Ischaemic Heart Disease (IHD) is a common health burden. Dyslipidemia is an established risk factor for the disease. Studies have been conducted to evaluate any possible relation of the disease with alterations of magnesium and potassium. But, among patients of Eastern India, studies to associate the condition with these analytes as well as their possible relationship with serum lipid profile have been rare. Aim: To evaluate the non diabetic, normotensive IHD patients attending a tertiary care hospital to find out whether there was any association of the disease with altered serum magnesium and potassium and to detect possible correlation of these electrolytes with serum lipid levels. Materials and Methods: This case-control study was conducted in the Departments of Biochemistry and Medicine of the Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India, from January 2019 to June 2020. This study included 106 non diabetic, normotensive IHD cases {encompassing 52 Chronic Coronary Syndrome (CCS) and 54 Acute Myocardial Infarction (AMI) patients} along with 103 age and sex-matched healthy controls. Serum magnesium, potassium and lipid profiles were assessed. Student’s unpaired t-test and Pearson correlation tests were performed using Statistical Package for the Social Sciences (SPSS) version 23 software. Results: The case and control groups were comparable for age and gender distribution as no statistically significant difference was found. The cases had a significantly lower serum magnesium and potassium (p<0.001 in each case) than the controls. There were significant positive correlations between serum Magnesium (Mg) and Potassium (K) (r=0.498, p<0.001) while significant negative correlations (r=-0.204, p=0.036) were established between magnesium and low density lipoprotein cholesterol of the cases. Conclusion: Low levels of serum magnesium and potassium are associated with coronary heart disease. Patients with deranged lipid profile should be regularly screened for deficiencies in serum magnesium. Further longitudinal studies are warranted to establish potential therapeutic role of supplementation of magnesium and potassium in IHD.
缺血性心脏病患者血清镁、钾含量及其与血脂相关性的研究
缺血性心脏病(IHD)是一种常见的健康负担。血脂异常是该疾病的一个确定的危险因素。已经进行了研究,以评估这种疾病与镁和钾的改变之间的任何可能的关系。但是,在印度东部的患者中,将这种疾病与这些分析物以及它们与血清脂质谱的可能关系联系起来的研究很少。目的:评价在三级医院就诊的非糖尿病、血压正常的IHD患者,以了解该疾病是否与血清镁、钾改变有关,并检测这些电解质与血脂水平的可能相关性。材料与方法:本病例对照研究于2019年1月至2020年6月在印度西孟加拉邦加尔各答研究生医学教育与研究所生物化学系和医学系进行。这项研究包括106例非糖尿病、血压正常的IHD病例(包括52例慢性冠状动脉综合征(CCS)和54例急性心肌梗死(AMI)患者)以及103例年龄和性别匹配的健康对照。测定血清镁、钾和血脂。学生的非配对t检验和Pearson相关检验使用社会科学统计软件包(SPSS)第23版软件进行。结果:病例组与对照组在年龄和性别分布上具有可比性,无统计学差异。这些病例的血清镁和钾明显低于对照组(p<0.001)。血清镁(Mg)与钾(K)呈显著正相关(r=0.498, p<0.001),镁与低密度脂蛋白胆固醇呈显著负相关(r=-0.204, p=0.036)。结论:血清镁、钾水平低与冠心病有关。血脂异常的患者应定期筛查血清镁缺乏。进一步的纵向研究有必要确定补充镁和钾对IHD的潜在治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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