Prevalence of SARS-CoV-2 Infection among Health Care Workers of a Hybrid Tertiary COVID-19 Hospital in Kerala, India

SJ Jessy, Shamha Beegum, S. Genga, G. Bindu, S. Chintha, Sukshma Sasidharan, A. Tonio, A. Reghukumar
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引用次数: 1

Abstract

Introduction: Health Care Workers(HCWs) have more risk of exposure, and those working in critical care units are likely to have exposure to higher viral inoculum load from aerosol generating procedures. The risk of acquisition of infection is higher in those who work in hybrid hospitals compared to those designated as Coronavirus Disease-2019 (COVID-19) hospitals. Aim: To estimate the prevalence of Severe Acute Respiratory Syndrome-Coronavirus-2019 (SARS-CoV-2) infection among Health Care Workers (HCWs) of a hybrid COVID-19 treatment hospital in Kerala. Materials and Methods: This cross-sectional study was conducted in the Central Biochemistry Laboratory, Government Medical College, Thiruvananthapuram, Kerala, India, during the period 8th January 2021 to 19th January 2021. Among 3550 HCWs, 979 subjects were selected and grouped into high risk and low risk category, based on their job profile in the hybrid hospital. Results: Finally, 940 HCWs were analysed in the study grouped as high risk (n=859) and low risk (n=81). SARS-CoV-2 Immunoglobulin (Ig) was detected in 180/940 (19.1%) of them. Seroprevalence among the high-risk group was 20.3% (174/859) and that in low-risk group was 7.4% (6/81) (p=0.005). In high-risk group, seropositivity was noted in 30.54 % (76/249) of nurses, 19% hospital attenders (30/158), 18.9% (59/312) resident doctors and 6.4% (9/140) consultant doctors. In those with a positive history of SARS-CoV-2 infection, seropositivity was found among 75.4% (101/134). In those who were COVID-19 positive during July 2020, 33.3% (6/18) were still IgG reactive. Conclusion: The study reported 19.1% SARS-CoV-2 IgG reactivity among HCWs. Seropositivity was significantly higher in high-risk group compared to low-risk. Antibody decay kinetics was comparable to that in published literature. Infection control challenges in hybrid hospitals account for higher seropositivity in this study, compared to overall seroprevalence among HCWs in Kerala.
印度喀拉拉邦一家新型冠状病毒混合三级医院医护人员SARS-CoV-2感染流行情况
卫生保健工作者(HCWs)有更多的暴露风险,那些在重症监护病房工作的人很可能暴露于气溶胶产生过程中较高的病毒接种量。与被指定为2019冠状病毒病(COVID-19)的医院相比,在混合医院工作的人员感染的风险更高。目的:了解喀拉拉邦某新型冠状病毒混合治疗医院医护人员SARS-CoV-2感染情况。材料和方法:本横断面研究于2021年1月8日至2021年1月19日期间在印度喀拉拉邦蒂鲁凡南塔普兰政府医学院中央生物化学实验室进行。在3550名卫生保健员中,根据其在混合医院的工作概况,选择979名受试者分为高风险和低风险两类。结果:940例HCWs分为高危组(n=859)和低危组(n=81)。其中180/940例(19.1%)检出SARS-CoV-2免疫球蛋白(Ig)。高危组血清阳性率为20.3%(174/859),低危组为7.4% (6/81)(p=0.005)。高危人群中,30.54%的护士(76/249)、19%的医院护理人员(30/158)、18.9%的住院医生(59/312)和6.4%的会诊医生(9/140)血清阳性。在有SARS-CoV-2感染史的人群中,血清阳性率为75.4%(101/134)。在2020年7月COVID-19阳性的人中,33.3%(6/18)仍有IgG反应。结论:卫生保健工作者SARS-CoV-2 IgG反应率为19.1%。高危组血清阳性率明显高于低危组。抗体衰变动力学与已发表的文献相当。在这项研究中,与喀拉拉邦卫生保健工作者的总体血清阳性率相比,混合医院的感染控制挑战导致了更高的血清阳性率。
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