Spectrum of Orbito-ocular Tumour in India: Histopathological and Immunohistochemical Study

Mousumi Sharma, P. Jaiswal, Nausheen S. Khan
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Abstract

Introduction: Orbito-ocular tumours are an important cause of morbidity and mortality. Their incidence is low but requires immediate diagnosis and treatment. There are limited research studies on histopathological and immunohistochemical studies of ocular tumour from India and these studies may provide valuable information and aid in accurate diagnosis and management. Aim: To elucidate distribution of age, sex, location of tumour, histopathological, immunohistochemical findings and any other relevant information with respect to orbito-ocular tumours. Materials and Methods: A retrospective observational analysis was conducted over a period of five years from March 2008 to February 2013, in the Department of Pathology in a tertiary care center, Assam, India. Hospital records of 55 patient with malignant ocular tumours were collected, reviewed and statistically analysed. Results: In the present study, a total of 55 cases were included. Out of which, two cases were inconclusive due to inadequate material. Remaining, 53 cases included both intraocular and orbital malignant tumours. Tumours were found slightly more in males (34 cases) compared to females (19) with a ratio of 1.8 to 1. Squamous Cell Carcinoma (SCC) comprised the maximum number (16 cases) followed by Retinoblastoma (RB) in 15 cases and melanoma in 11 cases. In children most common malignancy was RB followed by rhadomyosarcoma (RMS). Conclusion: In this study it was found that SCC was the most common malignant tumour in adults whereas RB was the most common tumour in children.
印度眼窝肿瘤的光谱:组织病理学和免疫组织化学研究
眼窝肿瘤是发病率和死亡率的重要原因。其发病率低,但需要立即诊断和治疗。印度眼部肿瘤的组织病理学和免疫组织化学研究有限,这些研究可能为准确诊断和治疗提供有价值的信息和帮助。目的:探讨眼眶-眼部肿瘤患者的年龄、性别、肿瘤位置、组织病理、免疫组化及其他相关信息。材料和方法:2008年3月至2013年2月,在印度阿萨姆邦一家三级保健中心的病理学部进行了回顾性观察分析,为期五年。对55例眼部恶性肿瘤患者的住院记录进行回顾性分析。结果:本研究共纳入55例。其中,有两起案件因材料不足尚无定论。其余53例包括眼内和眼眶恶性肿瘤。男性(34例)略多于女性(19例),比例为1.8比1。鳞状细胞癌(SCC)最多(16例),其次是视网膜母细胞瘤(RB)(15例)和黑色素瘤(11例)。儿童最常见的恶性肿瘤是RB,其次是横纹肌肉瘤(RMS)。结论:本研究发现SCC是成人中最常见的恶性肿瘤,而RB是儿童中最常见的肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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