Evaluation of Immature Platelet Fraction in Patients with Fever and Thrombocytopenia and its Clinical Utility

Narasingamoorthy Lavanya, B. Jayanthi
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引用次数: 0

Abstract

Introduction: Thrombocytopenia is very common in dengue and other haematological disorders and the aetiology is multifactorial. Immature Platelet Fraction (IPF) is a novel parameter which is a measure of reticulated platelets and it reflects the rate of regeneration of platelets. Aim: To evaluate the relationship between the IPF and platelet recovery and the consistency of its expression. Materials and Methods: The present study was a retrospective observational study done at Institute of Pathology, Madras Medical College between November 2018 to December 2018. Total 37 patients having fever with thrombocytopenia in dengue and other haematological causes were included for analysis. The platelet count, IPF, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Plateletcrit (PCT) was evaluated at the time of admission and once in every 24 hours and plotted in excel spread sheet. Results: About 86.4% were recovered in 24 hours after attaining the peak, 89.1% showed recovery in 24-48 hours of the rise of the IPF compared to the previous value and 94.5% recovered within 24 hours after the fall in the IPF value. It was observed that 81.8% were recovered when the IPF value ≥10% within 24- 48 hours. IPF readings are able to appreciate even in low platelet count levels but the other platelet recovery parameters did not. Conclusion: IPF is a consistent and reliable marker which can be measured even when the platelet count is low and it also predicts the platelets recovery. It is a promising marker that helps in guiding the decision towards platelet transfusion.
发热伴血小板减少患者未成熟血小板分数的评价及其临床应用
血小板减少症在登革热和其他血液病中很常见,其病因是多因素的。未成熟血小板分数(IPF)是衡量网状血小板的一个新参数,它反映了血小板的再生速度。目的:探讨IPF与血小板恢复的关系及其表达的一致性。材料与方法:本研究是一项回顾性观察性研究,于2018年11月至2018年12月在马德拉斯医学院病理研究所完成。共纳入37例登革热发热伴血小板减少及其他血液学原因患者进行分析。在入院时和每24小时评估一次血小板计数、IPF、平均血小板体积(MPV)、血小板分布宽度(PDW)和血小板电积(PCT),并绘制在excel电子表格中。结果:86.4%的患者在达到峰值后24小时内恢复,89.1%的患者在IPF值较前升高24-48小时内恢复,94.5%的患者在IPF值下降后24小时内恢复。当IPF值≥10%时,24 ~ 48 h内恢复率为81.8%。即使在低血小板计数水平下,IPF读数也能升值,但其他血小板恢复参数却没有。结论:IPF是一个稳定可靠的指标,即使在血小板计数低的情况下也能检测到,并能预测血小板恢复。这是一个有前途的标志物,有助于指导血小板输注的决定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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71
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12 weeks
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