Neutrophil Lymphocyte Ratio and Serum Ferritin Levels in COVID-19: A Cross-sectional Study

Shashi Upreti, S. Petwal, Anupama Arya, Aditi Upreti, Narayan Mihir, Sana Umar
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Abstract

Introduction: Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) causing Coronavirus Disease (COVID-19) has challenged the world. A complete blood workup as well as continuous tracking of haematological parameters play a vital role in revealing the risks of disease progression and eventually help in better treatment and outcome. Aim: To access the haematological parameters {Complete Blood Count (CBC), Neutrophil Lymphocyte Ratio (NLR) and Serum Ferritin (S. ferritin) levels} in COVID-19 patients to correlate its association with the severity of the disease. Materials and Methods: The present study was a cross-sectional study in which 200 patients who were confirmed as COVID-19 positive by real time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) in the month of July-August 2020 were included. Blood was collected from patients of COVID-19 using the routine methods and was evaluated for CBC and S. ferritin levels. Neutrophil Lymphocyte Ratio (NLR) was also calculated. Results: The NLR was positively correlated with severity of COVID-19. Patients with higher NLR levels were admitted to Intensive Care Unit (ICU) because of severity in their condition. In the present study, 42 of 47 (89.4%) ICU patients had S. ferritin levels >1000 ng/mL whereas only 8 (5.2%) of non ICU patients had S. ferritin levels >1000 ng/mL. Conclusion: The NLR and S. ferritin positively correlated with the severity of COVID-19 disease.
COVID-19中性粒细胞淋巴细胞比率和血清铁蛋白水平:一项横断面研究
简介:由SARS-CoV-2引起的冠状病毒病(COVID-19)已经挑战了世界。完整的血液检查和持续跟踪血液学参数在揭示疾病进展的风险并最终有助于更好的治疗和结果方面起着至关重要的作用。目的:获取COVID-19患者的血液学参数{全血细胞计数(CBC)、中性粒细胞淋巴细胞比率(NLR)和血清铁蛋白(S.铁蛋白)水平},以探讨其与疾病严重程度的相关性。材料与方法:本研究是一项横断面研究,纳入2020年7 - 8月通过实时逆转录-聚合酶链反应(RT-PCR)确诊为COVID-19阳性的200例患者。采用常规方法采集COVID-19患者血液,评估CBC和S.铁蛋白水平。同时计算中性粒细胞淋巴细胞比率(NLR)。结果:NLR与COVID-19严重程度呈正相关。NLR水平较高的患者因病情严重而被送入重症监护病房(ICU)。在本研究中,47例ICU患者中有42例(89.4%)S.铁蛋白水平为>1000 ng/mL,而非ICU患者中只有8例(5.2%)S.铁蛋白水平为>1000 ng/mL。结论:NLR和S.铁蛋白与COVID-19疾病严重程度呈正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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12 weeks
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