Association of Elevated Serum hs-CRP Levels with the Development of Cardiovascular Disease in Known Cases of Hypothyroidism: A Case-control Study

Naved Ahmad, Mushir Ahmad, Akash Gupta, A. Sharma
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Abstract

Introduction: Hypothyroidism is linked with an increased risk of Cardiovascular Diseases (CVD) and associated risk factors, but there is little documented information available about its association with high-sensitivity C-Reactive Protein (hs-CRP). Aim: To analyse the association between hs-CRP and CVD in hypothyroidism. Materials and Methods: This case-control study was carried out among 159 participants (87 cases and 72 controls) from January 2015 to August 2016 in the Department of Biochemistry, in collaboration with Department of Medicine, Subharti Medical College, its associated Chatrapati Shivaji Subharti (CSS)Hospital, Meerut,Uttar Pradesh, India. The samples were divided into two groups, Cases (hypothyroid patients) and Control group. Blood sample (3 mL) was collected from each subject. Serum was separated from blood by centrifuging blood at 3000 rpm for 10 minutes. Estimation of hs-CRP was done on semiautoanalyser (Robonikreadwell touch) in clinical biochemistry laboratory. Lipid profile and other routine investigations were done by Vitros-250 autoanalyser Johnson & Johnson, USA. All the statistical analysis was done by using the Windows based Statistical Package for Social Sciences (SPSS) version 18.0. Student’s t-test and Pearson correlation analysis was applied and p-values <0.05 were taken as the level of significance. Results: The mean age of cases and controls were 47.50±7.9 and 41.66±9.3 respectively. The mean hs-CRP values in the subjects with hypothyroidism (cases) was 3.41 mg/L and in control was 2.10 mg/L (p-value <0.0001). The weight and waist circumference, were also significantly different (p-value <0.05) between the study groups. The hs-CRP had an insignificant correlation with the BMI (r=0.12, p=0.23) as well as with waist circumference (r=0.15, p=0.14). Non significant correlation was found in between the hs-CRP and the blood pressure. Conclusion: This study concludes that hs-CRP levels were significantly higher in patients with hypothyroidism when compared to the control group. A significant correlation was found between cardiovascular risk factors like total cholestrol and High density lipoprotein (HDL) and hs-CRP levels.
甲减患者血清hs-CRP水平升高与心血管疾病发展的关系:一项病例对照研究
简介:甲状腺功能减退与心血管疾病(CVD)及相关危险因素的风险增加有关,但关于其与高敏c -反应蛋白(hs-CRP)的关系的文献资料很少。目的:分析甲减患者hs-CRP与CVD的关系。材料与方法:本病例对照研究于2015年1月至2016年8月在印度北方邦密鲁特市Subharti医学院医学系及其附属的Chatrapati Shivaji Subharti (CSS)医院的生物化学系开展,共有159名参与者(87例和72例对照)。将样本分为两组:病例组(甲状腺功能减退患者)和对照组。每位受试者采集血液样本(3ml)。将血液在3000 rpm下离心10分钟,从血液中分离血清。采用临床生化实验室半自动分析仪(Robonikreadwell touch)测定hs-CRP。脂质谱和其他常规检查由美国强生公司的Vitros-250自动分析仪完成。所有统计分析均使用基于Windows的社会科学统计软件包(SPSS) 18.0版本进行。采用学生t检验和Pearson相关分析,以p <0.05为显著性水平。结果:病例和对照组的平均年龄分别为47.50±7.9岁和41.66±9.3岁。甲减组(例)hs-CRP均值为3.41 mg/L,对照组为2.10 mg/L (p值<0.0001)。体重和腰围在两组间也有显著差异(p值<0.05)。hs-CRP与BMI (r=0.12, p=0.23)和腰围(r=0.15, p=0.14)的相关性不显著。hs-CRP与血压无显著相关性。结论:本研究结论甲状腺功能减退患者hs-CRP水平明显高于对照组。心血管风险因素如总胆固醇、高密度脂蛋白(HDL)和hs-CRP水平之间存在显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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