Comparison of Lipid Profile in the Cord Blood in the Hypertensive and Non hypertensive Mothers: A Case-control Study

Abstract

Introduction: Cord blood would be a feasible and simple method for detecting cholesterol level at birth. Neonatal lipids level could serve as a guide to know the physiological levels of lipids required for maintaining the normal bodily mechanisms. Aim: To compare the cord blood lipid profile of 300 newborn babies born to hypertensive and normotensive mothers. Materials and Methods: The case-control study was done in the Department of Paediatrics, GCS Medical College, Hospital and Research Centre, Ahmedabad, Gujarat, India, for the period of one year from Jan 2019 to Jan 2020. A total of 300 pregnant ladies were included in the study. They were divided in two groups: group A consisted of 150 newborns who were born to 150 hypertensive mothers and group B consisted of 150 newborns who were born to 150 non hypertensive mothers. Five millilitres of cord blood were collected from the placental end of the umbilical vein, and then the serum was separated by centrifugation. Data was collected and mean±SD were calculated. Chi-square test and Mann Whitney test were done for statistical analysis. Results: When the cord blood was evaluated for the cholesterol, Triglyceride (TG) (p-value 0.001), High Density Lipoprotein (HDL) (p-value 0.001) and Low Density Lipoprotein (LDL) (p-value 0.001) level; it was found that in group A the levels were more in mean value as compared to the non hypertensive group, where the level was found to be lower than the mean value. The difference was found to be statistically significant. Conclusion: Hypertensive status of mother could impact neonatal lipid profile; however, larger prospective studies are required to validate these results.