Synthesis and antioxidant activity of a new 4-aminocoumarin derivative

Novica R. Ristić, N. Radulović, B. Dekić, Milenko N. Ristić, V. Dekić
{"title":"Synthesis and antioxidant activity of a new 4-aminocoumarin derivative","authors":"Novica R. Ristić, N. Radulović, B. Dekić, Milenko N. Ristić, V. Dekić","doi":"10.5937/UNIVTHO8-19770","DOIUrl":null,"url":null,"abstract":"Synthesis, spectral characterization, and evaluation of in vitro antioxidant activity of a new coumarin derivative, 4- ((1,3,4-thiadiazol-2-yl)amino)-3-nitro-2H-chromene-2-one, are described. The synthesis of the new product was performed in three reaction steps, with a good overall yield (78%). The structure was corroborated by detailed spectral analysis, including the 1D and 2D NMR experiments (1H- and 13C NMR; 1H-1H COSY, NOESY, HSQC, and HMBC). The in vitro antioxidant activity was evaluated using the DPPH test. The synthesized compound possesses a good free-radical scavenging activity, IC50=596.7±0.3 μg/ml, and can serve as a model for the synthesis of similar compounds with promising antioxidant effects.","PeriodicalId":22896,"journal":{"name":"The University Thought - Publication in Natural Sciences","volume":"8 1","pages":"27-32"},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The University Thought - Publication in Natural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5937/UNIVTHO8-19770","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Synthesis, spectral characterization, and evaluation of in vitro antioxidant activity of a new coumarin derivative, 4- ((1,3,4-thiadiazol-2-yl)amino)-3-nitro-2H-chromene-2-one, are described. The synthesis of the new product was performed in three reaction steps, with a good overall yield (78%). The structure was corroborated by detailed spectral analysis, including the 1D and 2D NMR experiments (1H- and 13C NMR; 1H-1H COSY, NOESY, HSQC, and HMBC). The in vitro antioxidant activity was evaluated using the DPPH test. The synthesized compound possesses a good free-radical scavenging activity, IC50=596.7±0.3 μg/ml, and can serve as a model for the synthesis of similar compounds with promising antioxidant effects.
一种新型4-氨基香豆素衍生物的合成及其抗氧化活性
本文报道了一种新的香豆素衍生物4-((1,3,4-噻二唑-2-基)氨基)-3-硝基- 2h -2- 1的合成、光谱表征和体外抗氧化活性评价。新产物的合成分三个步骤进行,总收率达到78%。详细的光谱分析证实了该结构,包括1D和2D NMR实验(1H-和13C NMR;1H-1H COSY, NOESY, HSQC, HMBC)。采用DPPH法评价其体外抗氧化活性。合成的化合物具有良好的自由基清除活性,IC50=596.7±0.3 μg/ml,可作为模型合成具有良好抗氧化作用的类似化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
审稿时长
4 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信