Receptores de progesterona e estradiol e Ki-67 no estroma e no epitélio de endometriose superficial e profunda

Q4 Medicine
Luiz Ferraz de Sampaio Neto, Maria Cecília Ferro, L. D. Garcia, B. Ribeiro
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引用次数: 0

Abstract

Introduction: Endometriosis is a hormone-dependent disease characterized by ectopic presence of endometrial tissue responsive to ovarian steroids. Estrogen and progesterone are the main regulators of endometrial tissue, and the expression of receptors of these hormones in the ectopic tissue seems to be related to the pathophysiology of the disease. Ki-67 is a marker of tissue proliferation and an important marker of epithelial kinetics. Endometriosis can be classified as superficial, in the peritoneum, and deep, when it extends into ligaments and other organs. Objective: Our objective was to analyze the expression of estrogen and progesterone receptors and Ki-67, through immunohistochemistry, in different sites of endometriosis tissues (superficial peritoneal/ovarian endometriosis and deep infiltrating endometriosis). Casuistic and methods: We studied nine patients; five with superficial and four with deep endometriosis. Statistical correlation was performed with the Shapiro-Wilk test (significance level of 5%) and linear correlation analysis using Spearman’s non-parametric test (significance of 1%). There was a correlation of Spearman between the estrogen receptor variable and Ki-67 in patients with superficial endometriosis. There was also a correlation between the variables estrogen receptor and progesterone receptor in patients with deep endometriosis. Results: Contrary to what was found for superficial endometriosis, there is linear increase of the variables, with a strong and positive correlation coefficient. This demonstrates that the variation of estrogen receptors can be explained in 99.1% by the same variation of progesterone receptors in deep endometriosis. Conclusion: It is possible to infer that other factors are involved in the response to hormonal variations for superficial and deep endometriosi s.
浅部和深层子宫内膜异位症间质和上皮中的孕酮、雌二醇和Ki-67受体
简介:子宫内膜异位症是一种激素依赖性疾病,其特征是子宫内膜组织异位,对卵巢类固醇有反应。雌激素和孕激素是子宫内膜组织的主要调节因子,这些激素受体在异位组织中的表达似乎与疾病的病理生理有关。Ki-67是组织增殖的标志,也是上皮动力学的重要标志。子宫内膜异位症可分为浅表性(在腹膜)和深部(当它延伸到韧带和其他器官)。目的:通过免疫组化分析子宫内膜异位症(浅表性腹膜/卵巢子宫内膜异位症和深浸润性子宫内膜异位症)不同部位雌激素、孕激素受体及Ki-67的表达。方法:我们研究了9例患者;五个是浅表子宫内膜异位症,四个是深部子宫内膜异位症。统计学相关采用Shapiro-Wilk检验(显著性水平为5%),线性相关分析采用Spearman非参数检验(显著性水平为1%)。浅表性子宫内膜异位症患者雌激素受体变量与Ki-67有Spearman相关性。深子宫内膜异位症患者雌激素受体和孕激素受体之间也存在相关性。结果:与浅表性子宫内膜异位症相反,各变量呈线性增加,且具有强的正相关系数。这表明在深部子宫内膜异位症中,雌激素受体的变异与孕激素受体的变异有99.1%的相同。结论:浅表和深部子宫内膜异位症患者对激素变化的反应可能与其他因素有关。
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来源期刊
Jornal Brasileiro de Patologia e Medicina Laboratorial
Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology
CiteScore
1.30
自引率
0.00%
发文量
0
审稿时长
20 weeks
期刊介绍: The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.
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