Clinical profile of oral pemphigus vulgaris in Thai patients

IF 0.5 Q4 PRIMARY HEALTH CARE
R. Kaomongkolgit, W. Sarideechaigul, P. Klanrit, Pensri Phothipakdee
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引用次数: 2

Abstract

Background. Pemphigus vulgaris (PV) is a rare, life-threatening autoimmune disease and varies in its clinical profile and epidemiology in different regions of the world. Objectives. This study aimed to evaluate the demographic and clinical characteristics of oral PV patients in the lower north and northeast of Thailand. Material and methods. A retrospective study of PV patients who visited the Oral Medicine Clinic, Dental Hospital, Naresuan University and Khon Kaen University during the 2010–2020 period. Results. 21 oral PV patients were included. Among these, 16 (76.2%) were female, and 5 (23.8%) were male, with a female to male ratio of 3.2:1. The mean age of the patients was 47.7 ± 14.2 (range 25 to 74) years. 8 patients (38.1%) had a history of systemic diseases, and hypertension was predominant. The mean duration of the disease was 6 ± 3.42 (range 1 to 12) months. The most common complaint at presentation was oral ulceration with a burning sensation. The most affected sites were the buccal mucosa and gingiva (80.9%). Extraoral involvement was found in 14 patients (66.7%). Patients who had oral lesions before skin lesions found the mean duration was 4.63 ± 5.13 (range 1 to 16) months. Most of the patients (61.9%) were prescribed a combination of topical and systemic steroids. Conclusions. The present study illustrates the demographics and clinical characteristics of oral PV in Thai patients. Early diagnosis and timely treatment are critical for the patients. Since oral mucosa is often the first site of PV involvement, healthcare professionals must recognize the disease’s clinical characteristics and manage PV patients appropriately.
泰国口腔寻常型天疱疮患者的临床分析
背景。寻常型天疱疮(Pemphigus vulgaris, PV)是一种罕见的危及生命的自身免疫性疾病,其临床特征和流行病学在世界不同地区有所不同。目标。本研究旨在评估泰国北部和东北部口腔PV患者的人口统计学和临床特征。材料和方法。回顾性研究2010-2020年期间在口腔医学诊所、牙科医院、那理院大学和孔敬大学就诊的PV患者。结果:共纳入21例口腔PV患者。其中女性16例(76.2%),男性5例(23.8%),男女比例为3.2:1。患者平均年龄为47.7±14.2岁(25 ~ 74岁)。8例(38.1%)有全身性疾病史,以高血压为主。平均病程6±3.42(1 ~ 12)个月。最常见的主诉是口腔溃疡伴烧灼感。以颊黏膜和牙龈为主要受累部位(80.9%)。口腔外受累14例(66.7%)。在皮肤病变前出现口腔病变的患者,平均持续时间为4.63±5.13(1 ~ 16)个月。大多数患者(61.9%)使用局部和全身类固醇联合用药。结论。本研究阐明了泰国患者口腔PV的人口统计学和临床特征。早期诊断和及时治疗对患者至关重要。由于口腔黏膜通常是PV的第一个受损伤部位,医疗保健专业人员必须认识到该疾病的临床特征并适当地管理PV患者。
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来源期刊
CiteScore
1.20
自引率
14.30%
发文量
18
审稿时长
12 weeks
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