LIVER FUNCTION BIOMARKERS IN MALARIA AND HEPATITIS B CO-INFECTION AMONG PATIENTS WITH FEBRILE ILLNESS

A. A. Sharif, Muhammad Ibrahim Getso, Yusuf, I. Yusuf, I. Muhd, I. Ahmad
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引用次数: 5

Abstract

Introduction: Malaria and Hepatitis B Virus (HBV) co-infections present major threat to public health throughout tropical and Sub-Saharan Africa. This study was carried out to analyze the status of liver enzymes and serum protein in HBV and malaria co-infected patients in Murtala Muhammed Specialist Hospital (MMSH) Kano. Methods: Standard microscopy and rapid diagnostic test (RDT) were used separately to screen for mono and co-infections among 200 outpatients presented with fever. Their serum protein and liver enzymes were investigated. Results: Among the total subjects studied 25.5% were malaria positive. Females had higher rate of malaria infection (18%) than males (7.5%). Age group 15-24 had the highest malaria prevalence (11%). Thirteen (6.5%) subjects were HBV positive. Males had higher rate of infection (4.5%) than females (2.0%). Male subjects had higher prevalence of co-infection representing 4.5% and age groups 25-34 were observed to have highest co-infection rate of 1.5%. Biochemical parameters analyzed on all the categories of subjects shows significant difference in their mean values as compared to other groups (P<0.05). However no significant difference was observed in the value of ALP in all the groups. Statistical difference was also established in ALB values between the co-infection and malaria groups (P=0.037) and between malaria and control group (P=0.022). There is also a statistical difference in the mean value of total bilirubin among the groups P<0.05 and mean value of DB between HBV and control groups (P=0.022). Conclusion: The study showed that co-infection of malaria and HBV infection had no profound effect on the level of serum protein and liver enzyme activities in the serum.
发热性疾病患者中疟疾和乙型肝炎合并感染的肝功能生物标志物
疟疾和乙型肝炎病毒(HBV)合并感染对整个热带和撒哈拉以南非洲的公共卫生构成重大威胁。本研究旨在分析卡诺Murtala muhammad专科医院(MMSH) HBV和疟疾合并感染患者的肝酶和血清蛋白状况。方法:对200例发热门诊患者分别采用标准镜检和快速诊断试验(RDT)筛查单一感染和合并感染。测定血清蛋白和肝酶。结果:调查对象中疟疾阳性率为25.5%。女性疟疾感染率(18%)高于男性(7.5%)。15-24岁年龄组疟疾流行率最高(11%)。13例(6.5%)HBV阳性。男性感染率(4.5%)高于女性(2.0%)。男性受试者的合并感染率较高,为4.5%,25-34岁年龄组的合并感染率最高,为1.5%。各组生化参数均值与其他组比较差异有统计学意义(P<0.05)。各组间ALP值差异无统计学意义。合并感染组与疟疾组之间、疟疾组与对照组之间的ALB值也有统计学差异(P=0.037)。两组患者总胆红素均值P<0.05, DB均值与对照组比较,差异有统计学意义(P=0.022)。结论:研究表明,疟疾与HBV合并感染对血清蛋白水平和血清中肝酶活性无明显影响。
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