Plasma ghrelin in alcohol-dependent patients treated in addiction inpatient centres – preliminary research

Abstract

Introduction: Ghrelin is an orexigenic peptide produced mainly in gastric mucosa that may increase food hunger and likely psychoactive substance, including alcohol, craving. The aim of the study was to estimate blood ghrelin con-Streszczenie centration in alcohol-dependent patients (ADP) centres. Material and methods: Blood ghrelin concentration was examined twice in 67 alcoholics at the beginning of the study and after four weeks of alcohol abstinence, and in 61 social drinkers (control group) at the beginning of the study. Clinical, biochemical and anthropometric parameters of nutritional status were determined in all the study participants. Results: At the beginning of the study, ghrelin blood concentration was significantly lower in the studied persons than those from the control group. The ghrelin concentration in alcohol-de-pendent patients during four-week therapy increased. The independently to changes of ghrelin concentration alcohol craving did not increase and hunger remained stable. These changes of ghrelin were accompanied by an increase in body mass index (BMI) and mid muscle circumference as state of protein nutrition. Discussion: Further studies are needed to explain the clinical importance of the reverse relationships between blood ghrelin concentration and nutritional status in alcohol-dependent patients. Conclusions: The concentration of endogenus ghrelin in blood probably does not seem to be associated with alcohol craving but only with the intensity of drinking and alcohol-dependent patients’ nutritional status.