Primary Testicular Lymphoma: A Case Report and Review of the Literature

Nioka Pierre Xavier Sia, T. Chekrine, M. Bourhafour, Karima Ouadii, Z. Bouchbika, N. Benchakroun, H. Jouhadi, N. Tawfiq, A. Benider, F. Marnissi, A. Madani, M. Karkouri, S. Sahraoui
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引用次数: 1

Abstract

Background and Aim: Primary testicular lymphoma (PTL) is a rare form of extranodal non-Hodgkin’s lymphoma. It represents for 1% 2% of non-Hodgkin’s lymphoma, and mostly affects the elderly. We describe an interesting case of PTL managed by a combined multimodal approach with a review of the literature. Case Presentation: Patient aged 56 years, consulted for an increase in the volume of the right testicle without associated pain, all evolving in the context of a slight decline in general condition. Clinical examination revealed a large painless mass in the right scrotal bursa. A scrotal ultrasound showed a right intra-testicular mass. The patient had undergone inguinal orchiectomy. Pathological analysis showed diffuse large B-cell lymphoma of the testis. Whole-body 18-fluorodeoxyglucose positron emission tomography (18-FDGPET-CT) showed no suspicious hypermetabolism. Lumbar puncture did not reveal malignant cells in the cerebrospinal fluid (CSF). The patient then received 6 cycles of chemotherapy according to the R-CHOP protocol (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) and 2 cycles of intrathecal methotrexate. After chemotherapy, scrotal radiotherapy at a dose of 30 Gy was delivered. The evolution was marked by the death of the patient six months after the end of the scrotal radiotherapy following a diffuse lymph node relapse with a profound alteration of the general state. Conclusion: The treatment depends imperatively on the stage of the disease. The therapeutic approach is multimodal and combined based on orchiectoHow to cite this paper: Sia, N.P.X., Chekrine, T., Bourhafour, M., Ouadii, K., Bouchbika, Z., Benchakroun, N., Jouhadi, H., Tawfiq, N., Benider, A., Marnissi, F., Madani, A., Karkouri, M. and Sahraoui, S. (2022) Primary Testicular Lymphoma: A Case Report and Review of the Literature. Journal of Cancer Therapy, 13, 145-154. https://doi.org/10.4236/jct.2022.133011 Received: February 10, 2022 Accepted: March 18, 2022 Published: March 21, 2022 Copyright © 2022 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/
原发性睾丸淋巴瘤1例报告及文献复习
背景与目的:原发性睾丸淋巴瘤(PTL)是一种罕见的结外非霍奇金淋巴瘤。它占非霍奇金淋巴瘤的1% - 2%,主要影响老年人。我们描述了一个有趣的PTL案例,通过结合多模式方法管理,并回顾了文献。病例介绍:患者年龄56岁,因右睾丸体积增加而就诊,无相关疼痛,均在一般情况轻微下降的背景下发展。临床检查发现右侧阴囊囊内有一无痛性大肿块。阴囊超声显示右侧睾丸内肿块。患者行了腹股沟睾丸切除术。病理分析为睾丸弥漫性大b细胞淋巴瘤。全身18-氟脱氧葡萄糖正电子发射断层扫描(18-FDGPET-CT)未显示可疑的高代谢。腰椎穿刺未发现脑脊液(CSF)中有恶性细胞。然后患者接受R-CHOP方案6个周期化疗(利妥昔单抗、环磷酰胺、阿霉素、长春新碱、强的松)和2个周期鞘内甲氨蝶呤。化疗后给予阴囊放疗,剂量为30 Gy。这一进展的标志是患者在阴囊放疗结束6个月后死亡,原因是弥漫性淋巴结复发,总体状态发生了深刻的改变。结论:治疗应根据疾病分期而定。治疗方法是基于睾丸的多模式和联合治疗。如何引用这篇论文:Sia, N.P.X, Chekrine, T., Bourhafour, M., Ouadii, K., Bouchbika, Z., Benchakroun ., Jouhadi, H., Tawfiq, N., Benider, A., Marnissi, F., Madani, A., Karkouri, M.和Sahraoui, S.(2022)原发性睾丸淋巴瘤:一个病例报告和文献回顾。中华肿瘤杂志,2013,45- 45。https://doi.org/10.4236/jct.2022.133011收稿日期:2022年2月10日收稿日期:2022年3月18日出版日期:2022年3月21日版权所有©作者/作者:Scientific Research Publishing Inc。本作品采用知识共享署名国际许可协议(CC BY 4.0)。http://creativecommons.org/licenses/by/4.0/
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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