The Effect of Different Surgical Methods on the Number of Circulating Tumor Cells in the Peripheral Blood of Patients with Renal Cell Carcinoma

癌症治疗(英文) Pub Date : 2022-01-01 DOI:10.4236/jct.2022.131001

Dianbin Song, Zhi-yong Wang, Xiuming Li, Jingjing Zhang, Q. Chi, Hui Xu, Hong-Yang Li, Y. Liu

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Abstract

Objective: The objective is to explore the effects of different surgical methods-retroperitoneal laparoscopic radical nephrectomy (RLRN) and open radical nephrectomy (ORN) on the number of circulating tumor cells (CTC) in the peripheral blood of patients with renal cancer. Methods: The clinical data of 63 patients in the Department of Urology, Affiliated Hospital of Chengde Medical College who underwent radical surgery for renal cancer were divided into CTC positive group (18 cases of open surgery and 16 cases of minimally invasive surgery) and CTC negative group (14 cases of open surgery), 15 cases of minimally invasive surgery), overall group (32 cases of open surgery, 31 cases of minimally invasive surgery). Observe the changes in the number of CTC 1 week before operation and 1 week after operation. Results: In the positive group, whether it was open surgery or minimally invasive surgery, the postoperative CTC level of patients was significantly reduced (P < 0.05). In the negative group, the CTC decreased significantly after open surgery (P > 0.05), and the CTC level decreased significantly after minimally invasive surgery (P < 0.01). In the overall group, both open and minimally invasive surgery CTC decreased significantly, and the difference was statistically significant (P < 0.05). Conclusion: The two different surgical methods

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不同手术方式对肾细胞癌患者外周血循环肿瘤细胞数量的影响

目的:探讨后腹腔镜肾根治术(RLRN)和开放式肾根治术(ORN)不同术式对肾癌患者外周血循环肿瘤细胞(CTC)数量的影响。方法:将承德医学院附属医院泌尿外科行根治性肾癌手术的63例患者的临床资料分为CTC阳性组(开放手术18例，微创手术16例)、CTC阴性组(开放手术14例，微创手术15例)、整体组(开放手术32例，微创手术31例)。观察术前1周、术后1周CTC数的变化。结果:阳性组无论是开放手术还是微创手术，患者术后CTC水平均显著降低(P < 0.05)。阴性组开放术后CTC明显下降(P < 0.05)，微创术后CTC明显下降(P < 0.01)。在整体组中，开放和微创手术CTC均显著降低，差异有统计学意义(P < 0.05)。结论:两种手术方式不同

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癌症治疗(英文)

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