Research Article Genetic epidemiology of Type 2 diabetes mellitus and complications in the Brazilian population

IF 0.6 Q4 GENETICS & HEREDITY

Genetics and Molecular Research Pub Date : 2022-01-01 DOI:10.4238/gmr18969

J. S. Campos, K. F. Santos, C. Costa, J. Barros, V. Gonçalves, L.P. Assunção, A. Reis, R. Santos

引用次数: 0

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic, complex, multifactorial and polygenic disease, constituting one of the greatest public health challenges worldwide. The genetic background has been shown to strongly influence the disease’s susceptibility. We performed genetic screening of risk-variants for T2DM and complications in the Brazilian population. This systematic review is registered in the PROSPERO platform under number CRD42020153032. The searches were conducted in Virtual health library (BVS), EMBASE, Pubmed/NCBI, Scopus, and Web of Science databases, including only case-control studies that related genetic polymorphisms with the risk of developing the disease in the Brazilian population. Among the search results, we also extracted data regarding the susceptibility of developing macro/microvascular complications. Sixteen case-control studies were included, of which 10 addressed T2DM susceptibility and six the disease complications. A total of 4122 individuals were

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巴西人群中2型糖尿病及其并发症的遗传流行病学研究

2型糖尿病(T2DM)是一种慢性、复杂、多因素和多基因疾病，是全球最大的公共卫生挑战之一。遗传背景已被证明对这种疾病的易感性有很大影响。我们对巴西人群中T2DM和并发症的风险变异进行了遗传筛查。本系统综述已在PROSPERO平台注册，编号为CRD42020153032。检索是在Virtual health library (BVS)、EMBASE、Pubmed/NCBI、Scopus和Web of Science数据库中进行的，仅包括巴西人群中遗传多态性与发病风险相关的病例对照研究。在检索结果中，我们还提取了有关发生大/微血管并发症的易感性的数据。纳入16项病例对照研究，其中10项涉及T2DM易感性，6项涉及疾病并发症。共4122人

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来源期刊

Genetics and Molecular Research 生物-生化与分子生物学

CiteScore

1.00

自引率

25.00%

发文量

审稿时长

3 months

期刊介绍： Genetics and Molecular Research (GMR), maintained by the Research Foundation of Ribeirão Preto (Fundação de Pesquisas Científicas de Ribeirão Preto), publishes high quality research in genetics and molecular biology. GMR reflects the full breadth and interdisciplinary nature of this research by publishing outstanding original contributions in all areas of biology. GMR publishes human studies, as well as research on model organisms—from mice and flies, to plants and bacteria. Our emphasis is on studies of broad interest that provide significant insight into a biological process or processes. Topics include, but are not limited to gene discovery and function, population genetics, evolution, genome projects, comparative and functional genomics, molecular analysis of simple and complex genetic traits, cancer genetics, medical genetics, disease biology, agricultural genomics, developmental genetics, regulatory variation in gene expression, pharmacological genomics, evolution, gene expression, chromosome biology, and epigenetics.