Synthesis and Characterization of Heparin-Doped Polypyrrole Coatings Using an Electrochemical Quartz Crystal Microbalance (EQCM)

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-01-01 DOI:10.4152/pea.2022400104

D. Flamini, M. B. González, S. Saidman

引用次数: 1

Abstract

Polypyrrole (PPy) films were electrochemically synthesized on an Au/TiO 2 coated quartz crystal electrode in solutions with different heparin (Hep) concentrations. The PPy films morphology was determined by tapping a mode atomic force microscopy (AFM). The influence of the dopant concentration on the coating surface roughness was studied. Electrochemical quartz crystal microbalance (EQCM) results suggest that Hep retained in the PPy films was bound to thrombin. The adsorbed thrombin amount increased with a higher coating surface roughness. PPy films doped with Hep are electroactive and show cation exchange properties under oxidation or reduction conditions in a Ringer solution. The pre-oxidized PPy film adsorbed a greater thrombin amount than the freshly one and even more than the pre-reduced film.

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电化学石英晶体微天平(EQCM)合成掺杂肝素的聚吡咯涂层及表征

在不同浓度的肝素(Hep)溶液中，在Au/ tio2包覆石英晶体电极上电化学合成聚吡咯(PPy)薄膜。利用原子力显微镜(AFM)测定了聚吡啶薄膜的形貌。研究了掺杂剂浓度对涂层表面粗糙度的影响。电化学石英晶体微平衡(EQCM)结果表明，保留在PPy膜中的Hep与凝血酶结合。随着涂层表面粗糙度的增加，吸附凝血酶的量也随之增加。掺杂Hep的PPy薄膜具有电活性，在林格溶液中氧化或还原条件下表现出阳离子交换特性。预氧化的PPy膜吸附凝血酶的量大于新鲜的，甚至大于预还原的膜。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.