Partially Oxidized Polydiphenylamine for Sensitive Electrochemical Determination of Ceftazidime

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-01-01 DOI:10.4152/pea.202004229

K. Zarei, M. Lesani

引用次数: 2

Abstract

This work reports the development of a glassy carbon electrode (GCE), modified with an oxidized poly diphenylamine/multi-walled carbon nanotubes-β-cyclodextrin (OPDPA /MWCNT-β-CD) composite film, for ceftazidime determination. The OPDPA/MWCNT-β-CD film surface morphology was investigated using field emission scanning electron microscopy (FESEM) and cyclic voltammetry (CV). Ceftazidime was adsorbed onto the OPDPA/MWCNT-β-CD, at open circuit, for 240 seconds, and then oxidized in acidic media. The electrochemistry of ceftazidime oxidation was investigated using cyclic voltammetry and differential pulse voltammetry (DPV). Under optimum conditions, the peak current linearly increased with ceftazidime concentration, in the range of 5×10 M to 1×10 M. The obtained detection limit was 1.0×10 M. This sensor was employed for ceftazidime determination in the biological and pharmaceutical samples.

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部分氧化聚二苯胺灵敏电化学测定头孢他啶

本文报道了用氧化聚二苯胺/多壁碳纳米管-β-环糊精(OPDPA /MWCNT-β-CD)复合膜修饰的玻璃碳电极(GCE)，用于头孢他啶的测定。采用场发射扫描电镜(FESEM)和循环伏安法(CV)研究了OPDPA/MWCNT-β-CD膜的表面形貌。将头孢他啶在OPDPA/MWCNT-β-CD上开路吸附240秒，然后在酸性介质中氧化。采用循环伏安法和差分脉冲伏安法(DPV)研究了头孢他啶氧化的电化学过程。在最佳条件下，峰电流随头孢他啶浓度在5×10 M ~ 1×10 M范围内线性增加，得到的检出限为1.0×10 M。该传感器可用于头孢他啶在生物和医药样品中的检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.