An Electrochemical Sensor Based on Reduced Graphene Oxide Modified Carbon Paste Electrode for Curcumin Determination in Human Blood Serum

IF 1.1 Q4 ELECTROCHEMISTRY

Portugaliae Electrochimica Acta Pub Date : 2020-01-01 DOI:10.4152/pea.202001029

M. Rahimnejad, Rosan Zokhtareh, A. Moghadamnia, M. Asghary

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引用次数: 20

Abstract

A sensitive, accurate electrochemical sensor based on reduced graphene oxide modified carbon paste electrode (RGO/CPE) was developed to m easure curcumin levels in human blood serum. The as-prepared electrode (RGO/C PE) was verified to outperform bare carbon paste electrode (CPE), with increased o xidation and reduction peaks at +0.505 V and +0.408 V, respectively. Curcumin measu rement was performed using cyclic voltammetry (CV) and differential pulse volt ammetry (DPV) techniques. RGO/CPE showed a desirable linear response towards curcumin, within the concentration range of 10-6000 μM; the detection li mit (S/N = 3) was 3.183 μM. Moreover, electrochemical impedance spectroscopy (E IS) and field emission scanning electron microscope (FESEM) were applied to gain fu rther insight into the electrochemical behavior of the proposed electrode. Th results revealed that the usage of RGO caused increased sensitivity of the sensor r esponse to curcumin; therefore, RGO/CPE can be considered a promising electrochemic al sensor for curcumin determination in human blood serum.

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基于还原氧化石墨烯修饰碳糊电极的电化学传感器测定人血清中的姜黄素

研制了一种基于还原氧化石墨烯修饰碳糊电极(RGO/CPE)的灵敏、准确的电化学传感器，用于测定人血清中的姜黄素水平。制备的RGO/ CPE电极性能优于裸碳糊电极，在+0.505 V和+0.408 V处氧化峰和还原峰均有所增加。姜黄素的测定采用循环伏安法(CV)和差分脉冲伏安法(DPV)。在10 ~ 6000 μM的浓度范围内，RGO/CPE对姜黄素表现出良好的线性响应;检测li - mit (S/N = 3)为3.183 μM。此外，应用电化学阻抗谱(E IS)和场发射扫描电镜(FESEM)进一步了解所提出的电极的电化学行为。结果表明，RGO的使用增加了传感器对姜黄素的响应灵敏度;因此，RGO/CPE可以被认为是测定人血清中姜黄素的一种有前途的电化学传感器。

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来源期刊

Portugaliae Electrochimica Acta ELECTROCHEMISTRY-

CiteScore

2.30

自引率

16.70%

发文量

期刊介绍： Portugaliae Electrochimica Acta is a bi-monthly Journal published by the Portuguese Electrochemical Society since 1983. Portugaliae Electrochimica Acta publishes original papers, brief communications, reviews and letters concerned with every aspect of theory and practice of electrochemistry, as well as articles in which topics on history, science policy, education, etc. in the electrochemical field (teaching or research) may be discussed.