An Electrochemical Sensor Based on Reduced Graphene Oxide Modified Carbon Paste Electrode for Curcumin Determination in Human Blood Serum

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-01-01 DOI:10.4152/pea.202001029

M. Rahimnejad, Rosan Zokhtareh, A. Moghadamnia, M. Asghary

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引用次数: 20

Abstract

A sensitive, accurate electrochemical sensor based on reduced graphene oxide modified carbon paste electrode (RGO/CPE) was developed to m easure curcumin levels in human blood serum. The as-prepared electrode (RGO/C PE) was verified to outperform bare carbon paste electrode (CPE), with increased o xidation and reduction peaks at +0.505 V and +0.408 V, respectively. Curcumin measu rement was performed using cyclic voltammetry (CV) and differential pulse volt ammetry (DPV) techniques. RGO/CPE showed a desirable linear response towards curcumin, within the concentration range of 10-6000 μM; the detection li mit (S/N = 3) was 3.183 μM. Moreover, electrochemical impedance spectroscopy (E IS) and field emission scanning electron microscope (FESEM) were applied to gain fu rther insight into the electrochemical behavior of the proposed electrode. Th results revealed that the usage of RGO caused increased sensitivity of the sensor r esponse to curcumin; therefore, RGO/CPE can be considered a promising electrochemic al sensor for curcumin determination in human blood serum.

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基于还原氧化石墨烯修饰碳糊电极的电化学传感器测定人血清中的姜黄素

研制了一种基于还原氧化石墨烯修饰碳糊电极(RGO/CPE)的灵敏、准确的电化学传感器，用于测定人血清中的姜黄素水平。制备的RGO/ CPE电极性能优于裸碳糊电极，在+0.505 V和+0.408 V处氧化峰和还原峰均有所增加。姜黄素的测定采用循环伏安法(CV)和差分脉冲伏安法(DPV)。在10 ~ 6000 μM的浓度范围内，RGO/CPE对姜黄素表现出良好的线性响应;检测li - mit (S/N = 3)为3.183 μM。此外，应用电化学阻抗谱(E IS)和场发射扫描电镜(FESEM)进一步了解所提出的电极的电化学行为。结果表明，RGO的使用增加了传感器对姜黄素的响应灵敏度;因此，RGO/CPE可以被认为是测定人血清中姜黄素的一种有前途的电化学传感器。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.