Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

生物物理化学(英文) Pub Date : 2014-04-23 DOI:10.4236/JBPC.2014.52004

Ana Paula Caires dos Santos, M. S. Vieira, D. Deus, Rogério Jorge B. de Oliveira, A. Morikawa, Roque Aras Júnior, A. Atta, F. D. Couto, R. Maranhão, R. Couto

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引用次数: 4

Abstract

Dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HDL particle size and LDL particle size estimate based on TG/HDL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated hypertriglyceridemia (n = 17), low HDL-C (n = 26) and mixed dyslipidemia (n = 14). The HDL particle size did not differ between groups. The TG/HDL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HDL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I > 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p

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在血脂异常的情况下，动脉粥样硬化指数和高密度脂蛋白颗粒大小作为评估心血管风险的实验室参数

血脂异常可能影响脂蛋白颗粒重塑所需的酶和转运蛋白。计算指标和评价脂蛋白颗粒大小已被广泛用于预测心血管风险。本研究的目的是评估基于TG/HDL- c和apoB/apoA-I比值的HDL颗粒大小和LDL颗粒大小，分别作为血脂异常存在时心血管疾病风险的可能标记和动脉粥样硬化指标。我们评估了100名男女，未使用降脂药物治疗，27名正常血脂患者和73名血脂异常患者，如孤立性高胆固醇血症(n = 16)，孤立性高甘油三酯血症(n = 17)，低HDL-C (n = 26)和混合血脂异常(n = 14)。两组间HDL颗粒大小无差异。孤立性高甘油三酯血症组(4.2±1.5)、低HDL-C组(5.2±3.1)、混合性血脂异常组(5.3±1.6)TG/HDL-C比值较高。与正常血脂组(apoB/apoA-I = 0.5, p)相比，所有血脂异常组(apoB/apoA-I = 0.5)的apoB/apoA-I比值均升高

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来源期刊

生物物理化学(英文)

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144