Study of Nanoskin ECM-Bacterial Cellulose Wound Healing/United Arab Emirates

生物材料与纳米技术(英文) Pub Date : 2016-03-31 DOI:10.4236/JBNB.2016.72012

S. A. Mualla, R. Farahat, P. Basmaji, G. Olyveira, L. Costa, José C Oliveira, Gino Bruno Francozo

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引用次数: 9

Abstract

Natural extracellular matrices (ECMs) perform the tasks necessary for tissue formation, maintenance, regulation and function, providing a powerful means of controlling the biological performance of regenerative materials. In addition, biomedical materials have claimed attention because of the increased interest in tissue engineering materials for wound care and regenerative medicine. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this work, we present the extracellular matrix (ECM) using the bacterial cellulose (Nanoskin®) which regulates cell behavior by influencing cell proliferation, survival, shape, migration and differentiation. Bacterial cellulose fermentation process is modified before the bacteria are inoculated for mimicking ECM to cells support and built new local material for wound healing. Chemical groups influences and thermal behavior in bacterial cellulose were analyzed using transmission infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), respectively. Besides, In vivo analysis was evaluated with clinical study at Sharjah Kuwait Hospital.

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纳米皮肤ecm -细菌纤维素伤口愈合研究/阿拉伯联合酋长国

天然细胞外基质(ecm)执行组织形成、维持、调节和功能所必需的任务，为控制再生材料的生物性能提供了强有力的手段。此外，由于对伤口护理和再生医学的组织工程材料的兴趣增加，生物医学材料已经引起了人们的关注。此外，与胶原的纳米结构和形态相似性使BC具有用于细胞固定、细胞支持和天然细胞外基质(ECM)支架的吸引力。在这项工作中，我们提出了使用细菌纤维素(Nanoskin®)的细胞外基质(ECM)，它通过影响细胞增殖、存活、形状、迁移和分化来调节细胞行为。在细菌接种前对细菌纤维素发酵过程进行修改，以模拟ECM对细胞的支持，并构建新的局部材料用于伤口愈合。利用透射红外光谱(FTIR)和热重分析(TGA)分别分析了细菌纤维素中化学基团的影响和热行为。此外，在沙迦科威特医院的临床研究中对体内分析进行了评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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生物材料与纳米技术(英文)

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