Penicillin Resistance in Nasopharyngeal Streptococcus pneumoniae among Children with Sickle Cell Disease Immunized with 7-Valent Pneumococcal Conjugate Vaccine

P. B. B. Fonseca, C. Farhat, R. Succi, A. Machado, J. Braga
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引用次数: 5

Abstract

To assess the prevalence, the antimicrobials resistance and to identify risk factors of nasopharyngeal colonization by Streptococcus pneumoniae in children with sickle cell disease (SCD) using prophylactic penicillin and immunized with 7-valent pneumococcal conjugate vaccine. A total of 424 swabs were collected from the nasopharynx in 216 children with SCD and 109 samples from the control group, both from 2 to 60 months age range. Isolation and identification of pneumococci followed standard procedures. Minimum inhibitory concentration (MIC) for penicillin was determined by the E-test method. Prevalence of nasopharyngeal colonization by pneumococci in children with SCD was 17%, and 11% in the control group. The risk factors for increased colonization in children with SCD were the presence of more than five people at home, daycare/school attendance and low prophylaxis compliance. The prevalence of strains with penicillin resistance was 57.5% in patients with SCD and 25% in the control group. Conclusions: Prevalence of pneumococci nasopharyngeal colonization was similar among the study groups. Prophylactic use of penicillin may have increased the prevalence of resistant strains. The vaccine did not decrease the colonization with penicillin resistant strains.
7价肺炎球菌结合疫苗免疫儿童镰状细胞病鼻咽肺炎链球菌对青霉素的耐药性
目的评估预防性青霉素和7价肺炎球菌结合疫苗免疫的镰状细胞病(SCD)患儿肺炎链球菌鼻咽部定植的流行情况、耐药情况及危险因素。从216名SCD患儿和109名对照组患儿的鼻咽部共收集了424份拭子样本,年龄范围均为2至60个月。肺炎球菌的分离和鉴定遵循标准程序。采用e检验法测定青霉素的最低抑菌浓度(MIC)。SCD患儿鼻咽部肺炎球菌定植率为17%,对照组为11%。SCD儿童中菌落增加的危险因素是家中超过5人,日托/上学出勤率和低预防依从性。SCD患者中青霉素耐药菌株的患病率为57.5%,对照组为25%。结论:各研究组中肺炎球菌鼻咽部定植的患病率相似。预防性使用青霉素可能增加了耐药菌株的流行。该疫苗没有减少青霉素耐药菌株的定植。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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