Derivation of a Provisional, Age-dependent, AIS2+ Thoracic Risk Curve for the THOR50 Test Dummy via Integration of NASS Cases, PMHS Tests, and Simulation Data.

Q2 Medicine
T. R. Laituri, Scott Henry, Raed E. El-Jawahri, Nirmal Muralidharan, Guosong Li, Marvin Nutt
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引用次数: 3

Abstract

A provisional, age-dependent thoracic risk equation (or, "risk curve") was derived to estimate moderate-to-fatal injury potential (AIS2+), pertaining to men with responses gaged by the advanced mid-sized male test dummy (THOR50). The derivation involved two distinct data sources: cases from real-world crashes (e.g., the National Automotive Sampling System, NASS) and cases involving post-mortem human subjects (PMHS). The derivation was therefore more comprehensive, as NASS datasets generally skew towards younger occupants, and PMHS datasets generally skew towards older occupants. However, known deficiencies had to be addressed (e.g., the NASS cases had unknown stimuli, and the PMHS tests required transformation of known stimuli into THOR50 stimuli). For the NASS portion of the analysis, chest-injury outcomes for adult male drivers about the size of the THOR50 were collected from real-world, 11-1 o'clock, full-engagement frontal crashes (NASS, 1995-2012 calendar years, 1985-2012 model-year light passenger vehicles). The screening for THOR50-sized men involved application of a set of newly-derived "correction" equations for self-reported height and weight data in NASS. Finally, THOR50 stimuli were estimated via field simulations involving attendant representative restraint systems, and those stimuli were then assigned to corresponding NASS cases (n=508). For the PMHS portion of the analysis, simulation-based closure equations were developed to convert PMHS stimuli into THOR50 stimuli. Specifically, closure equations were derived for the four measurement locations on the THOR50 chest by cross-correlating the results of matched-loading simulations between the test dummy and the age-dependent, Ford Human Body Model. The resulting closure equations demonstrated acceptable fidelity (n=75 matched simulations, R2≥0.99). These equations were applied to the THOR50-sized men in the PMHS dataset (n=20). The NASS and PMHS datasets were combined and subjected to survival analysis with event-frequency weighting and arbitrary censoring. The resulting risk curve--a function of peak THOR50 chest compression and age--demonstrated acceptable fidelity for recovering the AIS2+ chest injury rate of the combined dataset (i.e., IR_dataset=1.97% vs. curve-based IR_dataset=1.98%). Additional sensitivity analyses showed that (a) binary logistic regression yielded a risk curve with nearly-identical fidelity, (b) there was only a slight advantage of combining the small-sample PMHS dataset with the large-sample NASS dataset,
通过整合NASS病例、PMHS试验和模拟数据,推导出THOR50试验假人的临时、年龄相关的AIS2+胸部风险曲线。
一个临时的,年龄相关的胸部风险方程(或“风险曲线”)被导出来估计中度至致命的伤害潜力(AIS2+),与高级中型男性测试假人(THOR50)测量的反应有关。推导涉及两个不同的数据源:来自现实世界的碰撞案例(例如,国家汽车抽样系统,NASS)和涉及死后人类受试者的案例(PMHS)。因此,推导更全面,因为NASS数据集通常倾向于年轻的居住者,而PMHS数据集通常倾向于年长的居住者。然而,已知的缺陷必须得到解决(例如,NASS病例有未知刺激,PMHS测试需要将已知刺激转化为THOR50刺激)。在NASS的分析部分,对THOR50大小的成年男性驾驶员的胸部损伤结果进行了收集,这些数据来自现实世界中11点1分的全碰撞正面碰撞(NASS, 1995-2012日历年,1985-2012车型年轻型乘用车)。筛选thor50大小的男性涉及应用一套新导出的“修正”方程,用于NASS中自我报告的身高和体重数据。最后,通过现场模拟估计THOR50刺激,包括伴随的代表性约束系统,然后将这些刺激分配给相应的NASS病例(n=508)。对于分析的PMHS部分,开发了基于模拟的闭合方程,将PMHS刺激转换为THOR50刺激。具体来说,通过交叉关联测试假人与年龄相关的福特人体模型之间的匹配加载模拟结果,推导出THOR50胸部四个测量位置的闭合方程。得到的闭合方程具有可接受的保真度(n=75匹配模拟,R2≥0.99)。这些方程应用于PMHS数据集中thor50大小的男性(n=20)。合并NASS和PMHS数据集,并进行事件频率加权和任意删减的生存分析。由此得出的风险曲线(THOR50胸部压迫峰值和年龄的函数)显示出可接受的保真度,可以恢复组合数据集的AIS2+胸部损伤率(即,IR_dataset=1.97%,而基于曲线的IR_dataset=1.98%)。额外的敏感性分析表明(a)二元逻辑回归产生的风险曲线具有几乎相同的保真度,(b)将小样本PMHS数据集与大样本NASS数据集结合使用只有轻微的优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Stapp car crash journal
Stapp car crash journal Medicine-Medicine (all)
CiteScore
3.20
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