Evaluation of the inflammatory predictive efficiency of progranulin as compared with common pro-inflammatory regulators

Q3 Biochemistry, Genetics and Molecular Biology
Nisreen W. Mustafa, Ola Naser, Zaid N. Elia, Sanaria F. Jarjes
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Abstract

Progranulin (PGRN), is a multifunctional protein with profound expression in epithelial and immune cells in which plays a crucial role in controlling host-defense signaling pathways during infection and inflammation. The current study carried out to evaluate the efficiency of progranulin as a predictive inflammatory marker for a group of diseases with different etiologies that cause acute and chronic inflammations. A total of 120 participants with various diseases (rheumatoid arthritis (RA), Helicobacter pylori infection, burn wound, hepatitis B and prostate cancer) in addition to 20 healthy people were enrolled in this study. The levels of serum PGRN and interleukin-6 (IL-6) were detected by enzyme-linked immunosorbent assay (ELISA), while chemiluminescent microparticle immunoassay (CMIA) was used to detect the concentrations of high-sensitive C-reactive protein (hsCRP). Elevated serum PGRN levels have been reported in all patient groups when compared with those in healthy controls (P > 0.05). Likewise, increased serum hsCRP and IL-6 levels were seen in all patient groups. However, for some patient groups, the differences in hsCRP and IL-6 levels did not reach statistical significance (P > 0.05) in comparison with control group. Furthermore, serum PGRN levels exhibited positive correlation with hsCRP in H. pylori and RA patient groups. As well as, with IL-6 only in RA patient group, whereas no significant correlations were found with the rest of studied diseases. This study concluded that progranulin is an effective nonspecific inflammatory indicator of acute and chronic inflammations. It had also a higher predictive efficiency than hsCRP and IL-6 which are commonly used as inflammatory predictive markers.
与普通促炎调节剂相比,前颗粒蛋白炎症预测效率的评估
前颗粒蛋白(PGRN)是一种在上皮细胞和免疫细胞中广泛表达的多功能蛋白,在感染和炎症过程中控制宿主防御信号通路中起重要作用。目前的研究是为了评估前颗粒蛋白作为一组不同病因引起急性和慢性炎症的疾病的预测炎症标志物的效率。共有120名患有各种疾病(类风湿关节炎(RA),幽门螺杆菌感染,烧伤伤口,乙型肝炎和前列腺癌)的参与者以及20名健康人参加了这项研究。采用酶联免疫吸附法(ELISA)检测血清PGRN和白细胞介素-6 (IL-6)水平,采用化学发光微粒免疫法(CMIA)检测血清高敏c反应蛋白(hsCRP)浓度。与健康对照组相比,所有患者组均报告血清PGRN水平升高(P < 0.05)。同样,所有患者组血清hsCRP和IL-6水平均升高。但部分患者组hsCRP、IL-6水平与对照组比较差异无统计学意义(P < 0.05)。此外,在幽门螺杆菌组和RA患者组中,血清PGRN水平与hsCRP呈正相关。此外,仅在RA患者组中与IL-6相关,而与其他研究疾病无显著相关性。本研究表明,前颗粒蛋白是急性和慢性炎症的有效非特异性炎症指标。它的预测效率也高于常用的炎症预测标志物hsCRP和IL-6。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Advanced Biotechnology and Experimental Therapeutics
Journal of Advanced Biotechnology and Experimental Therapeutics Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.90
自引率
0.00%
发文量
41
审稿时长
8 weeks
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