Cardiocurative effects of aqueous leaf extracts of Ximenia americana (linn.) and Pappea capensis (eckl. and zeyh.) against myocardial infarction in rats

Q3 Biochemistry, Genetics and Molecular Biology
D. Gaichu, P. Mathabe, M. Ngugi
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引用次数: 1

Abstract

Different plants are traditionally applied in the treatment of different diseases, including chest pains, hypertension, and inflammation, among others. This study scientifically evaluated the curative treatment effects of X. americana and P. capensis leaf aqueous extracts in rats induced with myocardial infarction. The rats were randomly distributed as follows: Normal control group, consisting of rats treated with oral normal saline; Negative control group, comprising rats induced with MI and treated with normal saline; Positive control group, consisting of rats induced with MI and orally treated with propranolol (10 mg/Kg bw); and three experimental groups consisting rats induced with MI and treated with plant extracts at dose levels 150, 200 and 250 mg/kg bw. This study’s findings demonstrated that there was a significant reduction in the amounts of cTnT, LDH, CK-MB, T-cholesterol, triglyceride, LDL, and malondialdehyde, as well as a significant increase in levels of HDL, catalase, SOD, and glutathione peroxidase among rats treated with propranolol and plant extracts as compared to the negative control rats. Additionally, LC-MS analysis revealed the presence of flavonoids, tannins, and phenolics, which could explain the observed cardiocurative effects. This study concluded that aqueous leaf extracts of X. americana and P. capensis possess cardiocurative activities in rats with myocardial infarction. However, further studies on isolated fractions of the phytochemicals present are recommended. This study provides preliminary data useful in the development of pure and safe cardioactive compounds.
美洲Ximenia americana (linn.)和木瓜capensis (eckl.)叶水提物的心脏治疗作用。对大鼠心肌梗塞的作用
传统上,不同的植物用于治疗不同的疾病,包括胸痛、高血压和炎症等。本研究科学评价了美洲蓟叶和capensis叶水提液对大鼠心肌梗死的治疗作用。大鼠随机分为:正常对照组,口服生理盐水;阴性对照组:心肌梗死诱导大鼠,生理盐水处理;阳性对照组:心肌梗死诱导大鼠,口服心得安(10 mg/Kg bw);以及3个实验组,分别是心肌梗死诱导大鼠和150、200和250 mg/kg bw剂量的植物提取物。本研究结果表明,与阴性对照大鼠相比,服用心得安和植物提取物的大鼠体内cTnT、LDH、CK-MB、t -胆固醇、甘油三酯、LDL和丙二醛的含量显著降低,HDL、过氧化氢酶、SOD和谷胱甘肽过氧化物酶水平显著增加。此外,LC-MS分析显示黄酮类、单宁和酚类物质的存在,这可以解释观察到的心血管作用。本研究结果表明,美洲蓟叶水提物和美洲蓟叶水提物对心肌梗死大鼠具有一定的心脏修复作用。然而,建议对存在的植物化学物质的分离组分进行进一步的研究。该研究为开发纯净、安全的心脏活性化合物提供了有用的初步数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Advanced Biotechnology and Experimental Therapeutics
Journal of Advanced Biotechnology and Experimental Therapeutics Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.90
自引率
0.00%
发文量
41
审稿时长
8 weeks
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