The Effects of Regulating Increased Blood Glucose Levels on Plasma Endothelin-1 Levels After Severe Head Trauma in Rats.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Turkish neurosurgery Pub Date : 2024-01-01 DOI:10.5137/1019-5149.JTN.43318-23.2

Mehmet Meral, Rahmi Kemal Koc, Ahmet Selcuklu

{"title":"The Effects of Regulating Increased Blood Glucose Levels on Plasma Endothelin-1 Levels After Severe Head Trauma in Rats.","authors":"Mehmet Meral, Rahmi Kemal Koc, Ahmet Selcuklu","doi":"10.5137/1019-5149.JTN.43318-23.2","DOIUrl":null,"url":null,"abstract":"Aim: To examine the effects of regulating increased blood glucose levels on plasma ET-1 levels after severe head trauma in rats.Material and methods: Traumatic diffuse brain injury-induced rats were followed for 7 days and were randomly divided into two groups of 36 rats. Pre- and posttraumatic blood glucose and ET-1 levels were measured in group 1 (control). Posttraumatic blood glucose levels were maintained at normal levels using insulin and both blood glucose and ET-1 levels were measured at 2, 6, 12, 24, and 48 h and 7 days posttrauma in group 2. The study excluded animals that died and had skull fractures.Results: Posttraumatic plasma ET-1 levels (n=36) were significantly higher than baseline values in group 1 (p < 0.05). ET-1 levels in group 2 at the 7-day follow-up after trauma were significantly higher than baseline values (n=36) (p < 0.05). However, the increased ET-1 levels were statistically significantly lower in group 2 than in group 1 (p < 0.05).Conclusion: The increased ET-1 levels were significantly prevented by keeping blood glucose levels within normal limits with insulin after severe head trauma. Thus, secondary injury to cerebral blood flow can be prevented by reducing the occurrence of vasospasm that starts in the early posttraumatic period or by stimulating the release of nitric oxide. Therefore, further studies on the role of ET-1 and insulin in developing secondary injuries after severe head trauma would be beneficial.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":"1 1","pages":"263-267"},"PeriodicalIF":0.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5137/1019-5149.JTN.43318-23.2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: To examine the effects of regulating increased blood glucose levels on plasma ET-1 levels after severe head trauma in rats.

Material and methods: Traumatic diffuse brain injury-induced rats were followed for 7 days and were randomly divided into two groups of 36 rats. Pre- and posttraumatic blood glucose and ET-1 levels were measured in group 1 (control). Posttraumatic blood glucose levels were maintained at normal levels using insulin and both blood glucose and ET-1 levels were measured at 2, 6, 12, 24, and 48 h and 7 days posttrauma in group 2. The study excluded animals that died and had skull fractures.

Results: Posttraumatic plasma ET-1 levels (n=36) were significantly higher than baseline values in group 1 (p < 0.05). ET-1 levels in group 2 at the 7-day follow-up after trauma were significantly higher than baseline values (n=36) (p < 0.05). However, the increased ET-1 levels were statistically significantly lower in group 2 than in group 1 (p < 0.05).

Conclusion: The increased ET-1 levels were significantly prevented by keeping blood glucose levels within normal limits with insulin after severe head trauma. Thus, secondary injury to cerebral blood flow can be prevented by reducing the occurrence of vasospasm that starts in the early posttraumatic period or by stimulating the release of nitric oxide. Therefore, further studies on the role of ET-1 and insulin in developing secondary injuries after severe head trauma would be beneficial.

查看原文本刊更多论文

调节大鼠头部严重创伤后血糖水平升高对血浆内皮素-1水平的影响

目的：研究调节大鼠严重头部创伤后血糖水平升高对血浆ET-1水平的影响：将弥漫性脑外伤大鼠随机分为两组，每组36只，随访7天。第 1 组（对照组）测量创伤前后血糖和 ET-1 水平。研究排除了死亡和颅骨骨折的动物：结果：第 1 组创伤后血浆 ET-1 水平（n=36）明显高于基线值（p < 0.05）。在创伤后 7 天的随访中，第 2 组的 ET-1 水平明显高于基线值（36 人）（p < 0.05）。然而，在统计学上，第 2 组 ET-1 水平的升高明显低于第 1 组（P < 0.05）：结论：严重头部创伤后，通过使用胰岛素将血糖水平控制在正常范围内，可明显防止 ET-1 水平升高。因此，可以通过减少创伤后早期开始的血管痉挛或刺激一氧化氮的释放来预防脑血流的二次损伤。因此，进一步研究 ET-1 和胰岛素在严重头部创伤后继发性损伤中的作用将是有益的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Turkish neurosurgery 医学-临床神经学

CiteScore

1.50

自引率

12.50%

发文量

126

审稿时长

2 months

期刊介绍： Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.