Naples Prognostic Score Predicts 6-Month Outcomes in Patients with Severe Traumatic Brain Injury: A Single-Center Retrospective Study.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Turkish neurosurgery Pub Date : 2024-01-01 DOI:10.5137/1019-5149.JTN.43209-22.3

Changcun Chen, Mingjiang Sun, Yutong Zhao, Rui Liu, Yuguang Tang, Hao Yang, Weiwei Shen, Zongyi Xie

{"title":"Naples Prognostic Score Predicts 6-Month Outcomes in Patients with Severe Traumatic Brain Injury: A Single-Center Retrospective Study.","authors":"Changcun Chen, Mingjiang Sun, Yutong Zhao, Rui Liu, Yuguang Tang, Hao Yang, Weiwei Shen, Zongyi Xie","doi":"10.5137/1019-5149.JTN.43209-22.3","DOIUrl":null,"url":null,"abstract":"Aim: To examine how Naples prognostic score (NPS) relates to 6-month outcomes in patients with severe traumatic brain injury (STBI).Material and methods: We retrospectively analyzed the clinical data of 94 patients with STBI between September 2018 and September 2021. Galizia?s method was used to calculate NPS, and patients were categorized as high (NPS > 3) or low (NPS?3) NPS according to their NPS scores based on receiver operating characteristic curve analysis. In addition, the controlling nutritional status score (CONUT) and prognostic nutrition index (PNI) were calculated. Based on the modified Rankin scale (mRS), the outcome for 6-months was evaluated. The mRS score for unfavorable outcomes was ?3.Results: In the univariate analyses, patients in the unfavorable group had higher NPS scores (p < 0.001). The multivariate analysis demonstrated that NPS was an independent predictor of poor outcomes after adjusting for potential confounding factors (adjusted odds ratio = 7.463, 95% confidence interval [CI]: 1.131?49.253, p < 0.05). The area under the NPS curve for predicting poor outcomes was 0.755 (95% CI: 0.655?0.837, p < 0.001), which was significantly higher than Glasgow coma score (GCS), CONUT, and PNI (NPS vs. GCS, p=0.013; NPS vs. CONUT, p=0.029; NPS vs. PNI, p=0.015).Conclusion: NPS can be considered to be a novel and better independent predictor of poor outcomes in patients with STBI.","PeriodicalId":23395,"journal":{"name":"Turkish neurosurgery","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5137/1019-5149.JTN.43209-22.3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: To examine how Naples prognostic score (NPS) relates to 6-month outcomes in patients with severe traumatic brain injury (STBI).

Material and methods: We retrospectively analyzed the clinical data of 94 patients with STBI between September 2018 and September 2021. Galizia?s method was used to calculate NPS, and patients were categorized as high (NPS > 3) or low (NPS?3) NPS according to their NPS scores based on receiver operating characteristic curve analysis. In addition, the controlling nutritional status score (CONUT) and prognostic nutrition index (PNI) were calculated. Based on the modified Rankin scale (mRS), the outcome for 6-months was evaluated. The mRS score for unfavorable outcomes was ?3.

Results: In the univariate analyses, patients in the unfavorable group had higher NPS scores (p < 0.001). The multivariate analysis demonstrated that NPS was an independent predictor of poor outcomes after adjusting for potential confounding factors (adjusted odds ratio = 7.463, 95% confidence interval [CI]: 1.131?49.253, p < 0.05). The area under the NPS curve for predicting poor outcomes was 0.755 (95% CI: 0.655?0.837, p < 0.001), which was significantly higher than Glasgow coma score (GCS), CONUT, and PNI (NPS vs. GCS, p=0.013; NPS vs. CONUT, p=0.029; NPS vs. PNI, p=0.015).

Conclusion: NPS can be considered to be a novel and better independent predictor of poor outcomes in patients with STBI.

查看原文本刊更多论文

那不勒斯预后评分可预测严重脑外伤患者 6 个月的预后：一项单中心回顾性研究。

目的：在危重疾病中，免疫营养状况对临床预后具有重要影响。有研究报告称，免疫营养指数那不勒斯预后评分（NPS）可准确预测各种疾病的预后。本研究旨在探讨 NPS 与严重创伤性脑损伤（STBI）患者 6 个月预后的关系：我们回顾性分析了2018年9月至2021年9月期间94名STBI患者的临床数据。采用Galizia法计算NPS，根据接收器操作特征曲线分析，根据NPS得分将患者分为高NPS（NPS 3）和低NPS（NPS ≤ 3）。此外，还计算了控制营养状况评分（CONUT）和预后营养指数（PNI）。根据改良Rank量表（mRS）评估了6个月的疗效。结果：在单变量分析中，不利组患者的 NPS 评分更高（P 0.001）。多变量分析表明，在调整了潜在的混杂因素后，NPS 是不良预后的独立预测因子（调整后的几率比 = 7.463，95% 置信区间 [CI]：1.131-49.25）：1.131-49.253, P 0.05).预测不良预后的 NPS 曲线下面积为 0.755（95% CI：0.655-0.837，P 0.001），显著高于格拉斯哥昏迷评分（GCS）、CONUT 和 PNI（NPS 与 GCS 相比，P = 0.013；NPS 与 CONUT 相比，P = 0.029；NPS 与 PNI 相比，P = 0.015）：结论：NPS可以被认为是STBI患者不良预后的一个新的、更好的独立预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Turkish neurosurgery 医学-临床神经学

CiteScore

1.50

自引率

12.50%

发文量

126

审稿时长

2 months

期刊介绍： Turkish Neurosurgery is a peer-reviewed, multidisciplinary, open access and totally free journal directed at an audience of neurosurgery physicians and scientists. The official language of the journal is English. The journal publishes original articles in the form of clinical and basic research. Turkish Neurosurgery will only publish studies that have institutional review board (IRB) approval and have strictly observed an acceptable follow-up period. With the exception of reference presentation, Turkish Neurosurgery requires that all manuscripts be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals.