Prediction of Preeclampsia: Role of Antiangiogenic and Proangiogenic Biomarkers

Abstract

The pathogenesis of preeclampsia (PE) is unknown, but recent studies have revealed that placenta is the place of origin of this disorder, and widespread maternal endothelial dysfunction is the charactertstic feature of the disease. Some biochemical molecules that are involved in the pathogenesis of the disease have recently been identified, which may help in early identification of patients at risk and help in providing proper prenatal care. Several promising biomarkers have been proposed, alone or in combination. Maternal serum concentrations of these biomarkers either increase or decrease in PE during gestation. This review focuses on the various biomarkers available and their utility in prediction and diagnosis of PE.