Chemoradiation Compared to Surgery Alone in Patients With Non- Metastatic Esophageal Carcinoma

Abstract

Purpose : To assess overall survival (OS) of esophageal cancer patients treated either by esophagectomy or chemoradiation (CRT). Methods: The medical records of patients with non metastatic esophageal cancer, treated with esophagectomy and those treated with concurrent CRT were analyzed. For all patients, files were reviewed for age, sex, tumor site and type, grade, disease stage and survival. The Log- rank test was used to examine differences in OS rates. Results: The medical records of 90 patients were analyzed. After a median follow up of 20 months, 2-year OS rate for the whole group was 46%. There was significant differences in 2-year OS in favor of patients treated by concurrent CRT (55.4%) compared to those treated by surgery (31%) (p=0.016, HR:1.96, 95% CI: 1.13–3.38). Univariate analysis showed that patients in each treatment group, had comparable 2-year OS rates regarding patient’s age, gender, pathologic subtype, and histologic grade (p>0.05). Disease stage in each group and tumor site in CRT group significantly affected OS rates (p<0.05). Conclusions: Survival rates were statistically significant higher in patients treated with CRT than in those underwent esophagectomy. Prognostic factors that affected survival were disease stage in each treatment group and tumor site in CRT group.