Metabolomic Profiling of Different Maca Color Types Using Nuclear Magnetic Resonance Spectroscopy and Multivariate Data Analysis

IF 0.6 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of the chemical society of pakistan Pub Date : 2022-01-01 DOI:10.52568/001071/jcsp/44.04.2022

Jingwei Lv Jingwei Lv, Chunnan Li Chunnan Li, Nanxi Zhang Nanxi Zhang, Kaiyue Z Kaiyue Z, Xiaochen Gao Xiaochen Gao, Na Li Na Li, Lingwen M Lingwen M, Yinping Y Yinping Y, Hui Zhang and Jiaming Sun Hui Zhang and Jiaming Sun

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引用次数: 0

Abstract

This study aimed to explore significant differences in chemical composition among maca (Lepidium meyenii Walp.) types with different colors in Yunnan province, China. 1H-NMR spectroscopy, in combination with principal component analysis and partial least squares discriminant analysis, was used to investigate the compounds responsible for compositional differences. Different maca color types in Yunnan were clearly distinguished by 11 differential metabolites. Furthermore, network pharmacology results showed that 30 active components were related to Alzheimer’s disease. Nine intersecting compounds among the 11 differential metabolites and 30 active components, namely, lysine, isoleucine, phenylalanine, β-hydroxybutyrate, tryptophan, pyroglutamate, proline, glutamine, and fructose, were used as bioactive markers to identify different maca color types. The results showed the bioactive markers among different maca color types holistically, providing a scientific basis for assessing the quality of commercial products derived from different maca color types.

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利用核磁共振波谱和多元数据分析不同玛卡颜色类型的代谢组学分析

为了探究云南不同颜色玛咖品种间化学成分的显著差异，采用1H-NMR、主成分分析和偏最小二乘判别分析相结合的方法对造成玛咖成分差异的化合物进行了分析。通过11种差异代谢物，明确了云南不同玛咖颜色类型。此外，网络药理学结果显示，30种活性成分与阿尔茨海默病有关。采用赖氨酸、异亮氨酸、苯丙氨酸、β-羟丁酸、色氨酸、焦谷氨酸、脯氨酸、谷氨酰胺和果糖等11种差异代谢物和30种活性成分中的9种交叉化合物作为玛卡不同颜色类型的生物活性标记物。结果显示了不同玛卡颜色类型间的生物活性标记物，为评价不同玛卡颜色类型的商品质量提供了科学依据。

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来源期刊

Journal of the chemical society of pakistan 化学-化学综合

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

3.4 months

期刊介绍： This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.