Suppression of β-Cell Apoptosis from H2O2-Induced Oxidative Stress in MIN6 cells using Methyl Gallate

IF 0.6 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of the chemical society of pakistan Pub Date : 2022-01-01 DOI:10.52568/000983/jcsp/44.01.2022

Tasneef Azam Tasneef Azam, Fouzia Noreen Fouzia Noreen, Bina S Siddiqui Bina S Siddiqui, Rahman M Hafizur Rahman M Hafizur, Sabira Begum Sabira Begum

引用次数: 0

Abstract

A major parameter for diabetic relevant diseases and hyperglycemia is the β-cell apoptosis. Anti diabetic drugs used widely these days chiefly target to lower hyperglycemia along with prevention of β-cells from apoptosis. In this study three natural products methyl gallate, syringic acid, and butanedioic acid from Myricaria germanica were analyzed for β-cell protection. Methyl gallate provided significant β-cell protection from H2O2-induced oxidative stress mediated apoptosis in MIN6 cells at 50 μM (95.5% and#177; 16.0 vs 57.6% and#177; 1.1) and at 100 μM (85.5% and#177; 7.0 vs 57.6% and#177; 1.1) concentrations.

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没食子酸甲酯抑制h2o2诱导的MIN6细胞β-细胞凋亡

糖尿病相关疾病和高血糖的一个重要参数是β细胞凋亡。目前广泛应用的抗糖尿病药物主要以降低高血糖和防止β细胞凋亡为目的。本研究分析了德国杨梅中三种天然产物没食子酸甲酯、丁香酸和丁二酸对β细胞的保护作用。50 μM下MIN6细胞h2o2诱导的氧化应激介导的凋亡中，没食子酸甲酯具有显著的β-细胞保护作用(95.5%，#177;16.0 vs 57.6%和#177;1.1)和100 μM(85.5%和#177;7.0 vs 57.6%和#177;1.1)浓度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the chemical society of pakistan 化学-化学综合

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

3.4 months

期刊介绍： This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.

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