Evaluation of anti-anxiety effects of the hydromethanolic extract of Boerhaavia diffusa L. roots in mice exposed to unpredictable chronic mild stress

IF 0.7 Q4 PLANT SCIENCES
M. Kumari, Prasanti Sharma, Neelima Sharma
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引用次数: 0

Abstract

Stress and anxiety are common psychiatric manifestations seen because of modern-day living especially expressed during demanding situations. Boerhaavia diffusa is an important medicinal plant widely used in the northeastern part of India. This study aimed to investigate the antioxidant and anti-anxiety activities of the hydro-methanolic extract of B. diffusa roots. The antioxidant property of the hydromethanolic extract of B.diffusa was determined by in vitro antioxidant assays such as DPPH scavenging activity. The cytotoxicity of the extract was investigated using SH-SY5Y cell lines and the anxiolytic activity was evaluated using the elevated plus maze test and open field tests. The results imply that the hydromethanolic extract of B. diffusa showed excellent antioxidant activity. The extract did not show any significant toxic effect on SH-SY5Y cells. The hydro-methanolic extract of B. diffusa also demonstrated significant anxiolytic activity at 100 and 200 mg/kg doses. Thus, it can be concluded that the hydromethanolic extract of B. diffusa possesses anxiolytic activity and antioxidant properties, proving its therapeutic usefulness in the treatment of anxiety disorders.
白花草根氢甲醇提取物对慢性轻度应激小鼠抗焦虑作用的评价
压力和焦虑是常见的精神病学表现,因为现代生活尤其是在苛刻的情况下表现出来。白花布尔哈维亚是印度东北部广泛使用的重要药用植物。本研究旨在研究白花根水甲醇提取物的抗氧化和抗焦虑活性。通过体外抗氧化实验(如清除DPPH)测定白花莲氢甲醇提取物的抗氧化性能。采用SH-SY5Y细胞株研究其细胞毒性,采用升高+迷宫试验和野外试验评价其抗焦虑活性。结果表明,白花草氢甲醇提取物具有良好的抗氧化活性。提取物对SH-SY5Y细胞无明显毒性作用。白花草水甲醇提取物在100和200 mg/kg剂量下也表现出显著的抗焦虑活性。综上所述,白花草氢甲醇提取物具有抗焦虑和抗氧化活性,证明了白花草对焦虑症的治疗作用。
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来源期刊
CiteScore
1.00
自引率
12.50%
发文量
1
审稿时长
52 weeks
期刊介绍: Indian Journal of Natural Products and Resources (IJNPR), a quarterly journal, is dedicated to the exploration of topics that confront both educators, frontline workers in the fields, entrepreneurs and ultimate users of the value added products and their resources pertaining to both plants and animals. It publishes original research papers, reviews and short communications. The scope of the journal is multidisciplinary especially of applied nature. Papers on plant cultivation, fishery, apiary, poultry, dairy, disease and pest control measures, postharvest technology/practices, value added products and utilization of plants and animals in broader sense (including ethnobotany and pharmacology) are considered for publication.
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