Starvation May Change the Type of Paternal but Not Maternal Inheritance of the Telomere Length Throughout Generations

Q3 Arts and Humanities

Collegium Antropologicum Pub Date : 2022-01-01 DOI:10.5671/ca.46.1.1

Leonid Kalichman, Anna M. Chumakova, Arcady Torchinsky, E. Kobyliansky

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引用次数: 0

Abstract

Our aim was to evaluate the effect of starvation on the paternal and maternal inheritance of the leucocyte telomere length (LTL) in three birth cohorts: before, during, and after the Chuvashian famine of 1922–1923. This retrospective cohort study comprised native Chuvash men (n= 678) and women (n=647) born between 1909–1980. Data were gathered during three expeditions: 1994, 1999, 2002, enabling us to treat age and birth year as independent variables. LTL was measured by a quantitative polymerase chain reaction technique. A significant difference in LTL values (χ2 d.f=2=79.04, p<0.0001) was observed between the sexes. In a pedigree-based variance component analysis, ~67.4% of the LTL variation was explained by an additive genetic component. In the entire sample, a significant correlation was observed between the LTL of the parents and offsprings. Fathers born between 1924–1928 demonstrated a significantly stronger LTL correlation with their offsprings. The LTL correlation between mothers and offspring in this group and between parents and offspring in those born after 1928 did not differ from the entire population. We believe that the increased correlation between the LTL in the father-offspring pairs born after starvation in Chuvashia can be explained by differences in the processes of oogenesis and spermatogenesis in humans.

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饥饿可能改变端粒长度的父系遗传类型，而不是母系遗传类型

我们的目的是评估饥饿对三个出生队列中父系和母系白细胞端粒长度(LTL)遗传的影响:在1922-1923年Chuvashian饥荒之前、期间和之后。本回顾性队列研究包括1909-1980年间出生的楚瓦什族男性(n= 678)和女性(n=647)。在1994年、1999年和2002年三次考察中收集的数据使我们能够将年龄和出生年份作为独立变量。LTL采用定量聚合酶链反应技术测定。两性间LTL值差异有统计学意义(χ2 d.f=2=79.04, p<0.0001)。在基于家系的方差成分分析中，~67.4%的LTL变异可由加性遗传成分解释。在整个样本中，父母和后代的LTL之间存在显著的相关关系。1924-1928年间出生的父亲与其后代的LTL相关性显著增强。在这个群体中，母亲和后代之间的LTL相关性以及1928年以后出生的父母和后代之间的LTL相关性在整个人群中没有差异。我们认为，在Chuvashia饥饿后出生的父系后代LTL之间的相关性增加可以通过人类卵子发生和精子发生过程的差异来解释。

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来源期刊

Collegium Antropologicum Social Sciences-Anthropology

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： International journal Collegium Antropologicum is the official journal of the Croatian Antropological Society and is jointly published by: Croatian Anthropological Society Croatian Association of Medical Anthropology - Croatian Medical Association Department of Natural Sciences, Anthropological Centre and the Scientific Council for Anthropological Research of the Croatian Academy of Sciences and Arts. With the numerous international recognition of co-operative experts, the Journal represents a relevant reference source in the fields of cultural and biological anthropology, sociology, ethnology, psychology, demography, history, archaeology, genetics, biomedicine, human ecology, nutrition and other fields related to multidisciplinary character of anthropology.